Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis

被引：22
作者：
Zhang, Wenfeng [1 ,2 ,3 ,4 ]
Wang, Jia [1 ,2 ,4 ]
Liu, Cun [3 ]
Li, Ye [1 ,2 ]
Sun, Changgang [1 ,2 ,3 ,5 ]
Wu, Jibiao [4 ]
Wu, Qibiao [1 ,2 ]
机构：
[1] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macau, Peoples R China
[2] Macau Univ Sci & Technol, Fac Chinese Med, Ave Wai Long, Taipa 999078, Macau, Peoples R China
[3] Weifang Med Univ, Coll Tradit Chinese Med, Weifang 261000, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250355, Peoples R China
[5] Weifang Tradit Chinese Hosp, Dept Oncol, Weifang 261000, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2023年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Cancer-associated fibroblasts; Tumor microenvironment; Metastasis; NERVE GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; VEGF-INDEPENDENT ANGIOGENESIS; TGF-BETA; STROMAL FIBROBLASTS; LUNG METASTASIS; NICHE FORMATION; LYMPH-NODE; CARCINOMA; PROMOTES;
D O I：
10.1186/s12967-023-04714-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs increases the dynamic complexity of the tumor microenvironment (TME). The intertwined network of the TME facilitates the interaction between activated CAFs and breast cancer cells, which can lead to the proliferation and invasion of breast cells. Considering the special transmission function of CAFs, the aim of this review is to summarize and highlight the crosstalk between CAFs and breast cancer cells in the TME as well as the relationship between CAFs and extracellular matrix (ECM), soluble cytokines, and other stromal cells in the metastatic state. The crosstalk between cancer-associated fibroblasts and tumor microenvironment also provides a plastic therapeutic target for breast cancer metastasis. In the course of the study, the inhibitory effects of different natural compounds on targeting CAFs and the advantages of different drug combinations were summarized. CAFs are also widely used in the diagnosis and treatment of breast cancer. The cumulative research on this phenomenon supports the establishment of a targeted immune microenvironment as a possible breakthrough in the prevention of invasive metastasis of breast cancer.
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页数：21
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