Acupuncture for painful diabetic peripheral neuropathy: a systematic review and meta-analysis

被引:7
作者
Zhou, Luolin [1 ]
Wu, Tong [1 ]
Zhong, Zhishan [1 ]
Yi, Lichen [1 ]
Li, Yuemei [2 ]
机构
[1] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China
[2] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Dept Rehabil, Guangzhou, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词
acupuncture therapy; painful diabetic peripheral neuropathy; alternative and complementary medicine; meta-analysis; systematic review; ELECTROACUPUNCTURE;
D O I
10.3389/fneur.2023.1281485
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Painful Diabetic Peripheral Neuropathy (PDPN) is a common complication of diabetes, it severely affects the quality of life of patients. Acupuncture has been shown to be effective in the treatment of PDPN. To evaluate the efficacy and safety of acupuncture for pain relief in patients diagnosed with diabetic peripheral neuropathy, we conducted a systematic review and meta-analysis.Method: We thoroughly searched specific databases, which included PUBMED, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, the Chinese National Knowledge Infrastructure, China Science and Technology Journal Database and the Wanfang Data. All randomized controlled trials of acupuncture therapy for PDPN with pain change scales were included. Included studies were assessed for methodological quality according to the risk of bias from the Cochrane handbook. Meta-analyses were carried out to analyze the outcomes, subgroup analyses, sensitivity analyses, and funnel plot analyses were undertaken.Results: This systematic review evaluated a total of 25 trials of acupuncture therapy in combination with conventional treatment, involving a total of 1,561 patients with PDPN. According to the results, among 16 trials using VAS scores with a total of 1,552 patients, 2 acupoint injection trials (MD -2.38, 95% CI: -2.76 to -2.01, p < 0.00001), 12 acupuncture trials (MD -1. 31, 95% CI: -1.60 to -1.02, p < 0.00001) and 2 moxibustion trials showed that acupuncture therapy combined with conventional treatment improved pain better than conventional treatment (MD -2.50, 95% CI: -2.76 to -2.24, p < 0.00001). In the subgroup analysis of the acupuncture group, the results of the 5 trials in which the location of acupuncture was only in the limbs (MD -1.27, 95% CI: -1.54 to -1.01, p < 0.00001) and the 7 trials both in limbs and torso (MD -1.38, 95% CI: -1.81 to -0.95, p < 0.00001) also demonstrated that acupuncture was effective in pain improvement.Conclusion: This meta-analysis analyzed the possible efficacy of acupuncture in combination with conventional treatment for pain in diabetic peripheral neuropathy, particularly when acupoints are located in the limbs. However, there are limitations to this meta-analysis and future clinical studies are needed to confirm these findings.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023449447, identifier (CRD42023449447).
引用
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页数:13
相关论文
共 67 条
  • [1] Ang Lynn, 2018, Diabetes Spectr, V31, P224, DOI 10.2337/ds18-0036
  • [2] Diabetic neuropathy
    不详
    [J]. Nature Reviews Disease Primers, 5 (1) : 42
  • [3] Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?
    Calcutt, Nigel A.
    [J]. PAIN, 2020, 161 (09) : S65 - S86
  • [4] Chang-hua M., 2016, Hospitals, V16, P1432, DOI [10.3969/j.issn.1671-332X.2016.10.008, DOI 10.3969/J.ISSN.1671-332X.2016.10.008]
  • [5] Chen Q., 2015, Hainan Med J, V26, P3537, DOI [10.3969/j.issn.1003-6350.2015.23.1279, DOI 10.3969/J.ISSN.1003-6350.2015.23.1279]
  • [6] Diabetic peripheral neuropathic pain: Recognition and management
    Cole, B. Eliot
    [J]. PAIN MEDICINE, 2007, 8 : S27 - S32
  • [7] Cui-xian L., 2008, Shanghai J Acupunct Moxibust, V1, P45, DOI [10.13460/j.issn.1005-0957.2008.01.025, DOI 10.13460/J.ISSN.1005-0957.2008.01.025]
  • [8] Deng C., 2014, J Clin Acupunct Moxibust, V30, P60
  • [9] Deng Xiu-Min, 2021, Zhongguo Zhen Jiu, V41, P23, DOI 10.13703/j.0255-2930.20200105-0004
  • [10] Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis
    Dimitrova, Alexandra
    Murchison, Charles
    Oken, Barry
    [J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2017, 23 (03) : 164 - 179