New Treatment Options in Metastatic Pancreatic Cancer

被引：12

作者：

Fudalej, Marta ^{[1
,2
]}

Kwasniewska, Daria ^{[2
]}

Nurzynski, Pawel ^{[2
]}

Badowska-Kozakiewicz, Anna ^{[1
]}

Mekal, Dominika ^{[1
]}

Czerw, Aleksandra ^{[3
,4
]}

Sygit, Katarzyna ^{[5
]}

Deptala, Andrzej ^{[1
,2
]}

机构：

[1] Med Univ Warsaw, Dept Oncol Propaedeut, PL-01445 Warsaw, Poland

[2] Minist Interior & Adm, Cent Clin Hosp, Dept Oncol, PL-02507 Warsaw, Poland

[3] Med Univ Warsaw, Dept Hlth Econ & Med Law, PL-01445 Warsaw, Poland

[4] Natl Inst Publ Hlth, Natl Res Inst, Dept Econ & Syst Anal, NIH, PL-00791 Warsaw, Poland

[5] Calisia Univ, Fac Hlth Sci, PL-62800 Kalisz, Poland

来源：

CANCERS | 2023年 / 15卷 / 08期

关键词：

pancreatic cancer; KRAS; oncology; targeted therapy; immunotherapy; TRIPLE ANGIOKINASE INHIBITOR; RANDOMIZED PHASE-II; DUCTAL ADENOCARCINOMA; POLYPLEX MICELLES; NAB-PACLITAXEL; TARGETING KRAS; GENE-THERAPY; GEMCITABINE; NANOPARTICLES; IMMUNOTHERAPY;

D O I：

10.3390/cancers15082327

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary The poor prognosis of pancreatic cancer (PC) is associated with several factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable resistance to most conventional treatment options. The pathogenesis of PC seems to be significantly more complicated than originally assumed. To develop effective treatment schemes prolonging patient survival, a multidirectional approach encompassing different aspects of the cancer is needed. Particular directions have been established; however, further studies bringing them all together and connecting the strengths of each therapy are needed. This review aims to provide an overview of new or emerging therapeutic strategies for the more effective management of metastatic PC. Pancreatic cancer (PC) is the seventh leading cause of cancer death across the world. Poor prognosis of PC is associated with several factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable resistance to most conventional treatment options. The pathogenesis of PC seems to be significantly more complicated than originally assumed, and findings in other solid tumours cannot be extrapolated to this malignancy. To develop effective treatment schemes prolonging patient survival, a multidirectional approach encompassing different aspects of the cancer is needed. Particular directions have been established; however, further studies bringing them all together and connecting the strengths of each therapy are needed. This review summarises the current literature and provides an overview of new or emerging therapeutic strategies for the more effective management of metastatic PC.

引用

页数：18

共 141 条

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