The Role of Interferons in Long Covid Infection

被引：4

作者：

Karbalaeimahdi, Mohammad ^{[1
,2
]}

Farajnia, Safar ^{[2
,3
,8
]}

Bargahi, Nasrin ^{[2
]}

Ghadiri-Moghaddam, Farzaneh ^{[3
,4
]}

Jazi, Hamid Reza Rasouli ^{[2
]}

Bakhtiari, Nasim ^{[2
]}

Ghasemali, Samaneh ^{[5
]}

Zarghami, Nosratollah ^{[6
,7
]}

机构：

[1] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[4] Azarbaijan Shahid Madani Univ, Fac Sci, Dept Biol, Tabriz, Iran

[5] Tabriz Univ Med Sci, Dept Student Res Comm, Tabriz, Iran

[6] Istanbul Aydin Univ, Fac Med, Dept Med Biochem, Istanbul, Turkiye

[7] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[8] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51656065811, Iran

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2023年 / 43卷 / 02期

关键词：

COVID-19; interferons; Long Covid infections; post-COVID-19; syndrome; VIRAL PERSISTENCE; VIRUS-INFECTION; GAMMA; AUTOIMMUNITY; MECHANISMS; SARS-COV-2; SEQUELAE; DISEASE;

D O I：

10.1089/jir.2022.0193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the new generation of vaccines and anti-COVID-19 treatment regimens facilitated the management of acute COVID-19 infections, concerns about post-COVID-19 syndrome or Long Covid are rising. This issue can increase the incidence and morbidity of diseases such as diabetes, and cardiovascular, and lung infections, especially among patients suffering from neurodegenerative disease, cardiac arrhythmias, and ischemia. There are numerous risk factors that cause COVID-19 patients to experience post-COVID-19 syndrome. Three potential causes attributed to this disorder include immune dysregulation, viral persistence, and autoimmunity. Interferons (IFNs) are crucial in all aspects of post-COVID-19 syndrome etiology. In this review, we discuss the critical and double-edged role of IFNs in post-COVID-19 syndrome and how innovative biomedical approaches that target IFNs can reduce the occurrence of Long Covid infection.

引用

页码：65 / 76

页数：12

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