Vitamin D Deficiency: An Underestimated Factor in Sepsis?

被引：19

作者：

Delrue, Charlotte ^{[1
]}

Speeckaert, Reinhart ^{[2
]}

Delanghe, Joris R. R. ^{[3
]}

Speeckaert, Marijn M. M. ^{[1
,4
]}

机构：

[1] Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Diagnost Sci, B-9000 Ghent, Belgium

[4] Res Fdn Flanders FWO, B-1000 Brussels, Belgium

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 03期

关键词：

vitamin D deficiency; sepsis; mortality; vitamin D treatment; CRITICALLY-ILL CHILDREN; ONSET NEONATAL SEPSIS; LENGTH-OF-STAY; PRETERM INFANTS; ANTIMICROBIAL PEPTIDES; 25-HYDROXYVITAMIN D; RISK-FACTORS; CATHELICIDIN; EXPRESSION; SUPPLEMENTATION;

D O I：

10.3390/ijms24032924

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin D is an important immune modulator that is linked to infection susceptibility. It has been suggested that vitamin D deficiency plays a role in sepsis and septic shock because vitamin-D-related pathways are associated with various immunological, endocrine, and endothelial functions. Previous research has yielded inconclusive results regarding the link between mortality and vitamin D deficiency in sepsis patients. In patients with sepsis and severe vitamin D deficiency, an adequate vitamin D concentration may reduce mortality. Randomized controlled trials to assess the influence of vitamin D supplementation on clinical outcomes in sepsis patients with vitamin D deficiency are uncommon. We will provide an overview of the current knowledge about the relationship between vitamin D and sepsis in this review, as well as consider the potential value of vitamin D supplementation in this situation.

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页数：21

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