SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression

被引：6
作者：
Li, Bing [1 ,2 ]
Dang, Xiaoqian [1 ]
Duan, Jiafeng [3 ]
Zhang, Guangyang [1 ]
Zhang, Jia [4 ,6 ]
Song, Qichun [1 ,5 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 2, Xian, Peoples R China
[2] Northwest Univ, Xian Hosp 3, Dept Orthopaed, Affiliated Hosp, Xian, Peoples R China
[3] Nobel Stomatol Hosp, Dept Implant, Xian, Peoples R China
[4] Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian, Peoples R China
[5] Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 2, Xian 710004, Shaanxi, Peoples R China
[6] Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710004, Shaanxi, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2023年 / 27卷 / 02期
关键词：
glycolysis; IDH1; osteosarcoma; SIX4; METASTASIS; GROWTH;
D O I：
10.1111/jcmm.17650
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the role of SIX4 in osteosarcoma progression remains unknown. The expression profile of SIX4 in OS was evaluated in surgery samples of osteosarcoma patients. Functional studies were performed in vitro and in vivo. We found that SIX4 is significantly overexpressed in osteosarcoma and related to the undesirable prognosis of osteosarcoma patients. SIX4 promotes progression of osteosarcoma via upregulating isocitrate dehydrogenase 1 (IDH1), which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.
引用
收藏
页码：259 / 265
页数：7
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