Synthesis, antimicrobial, and antioxidant activities of disubstituted 1,2,3-triazoles with amide-hydroxyl functionality

被引：6

作者：

Chahal, Manisha ^{[1
]}

Kaushik, Chander Prakash ^{[1
]}

Luxmi, Raj ^{[1
]}

Kumar, Devinder ^{[1
]}

Kumar, Ashwani ^{[1
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar, Haryana, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2023年 / 32卷 / 01期

关键词：

1; 4-disubstituted; 2; 3-triazoles; Cell-CuI NPs; Antioxidant activity; Antimicrobial activity; LINKED 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; INHIBITORS;

D O I：

10.1007/s00044-022-02993-w

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1,4-disubstituted 1,2,3-triazoles with amide-hydroxyl functionality (5a-5t) was synthesized from aliphatic alkynes (4a-4e) and aromatic bromides (3a-3d) in presence of catalytic amount of cellulose CuI nanoparticles. All the synthesized triazoles were characterized by various analytical techniques: FTIR, H-1 NMR, C-13 NMR and HRMS. Further, all the synthesized compounds were screened for in vitro antioxidant and antimicrobial activities. The antioxidant activity of the compound 5s was found better than other compounds. Compounds 5h and 5l exhibited good antibacterial and antifungal activity, respectively. The docking studies were performed to find out various binding interactions of protein-ligand complex. In silico ADME study was performed to evaluate their drug likeness.

引用

页码：85 / 98

页数：14

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