Photoinduced Nickel-Catalyzed Demethylative Cyanation and Decarboxylative Cyanomethylation of Aryl Halides

被引：11

作者：

Lee, Shao-Chi ^{[1
]}

Zhu, Chen ^{[2
]}

Huang, Kun ^{[1
]}

Bau, Jeremy A. ^{[1
]}

Jia, Jiaqi ^{[1
]}

Yue, Huifeng ^{[3
]}

Rueping, Magnus ^{[1
]}

机构：

[1] King Abdullah Univ Sci & Technol KAUST, KAUST Catalysis Ctr KCC, Thuwal 239556900, Saudi Arabia

[2] Eastern Inst Technol, Eastern Inst Adv Study, Ningbo 315200, Peoples R China

[3] Fuzhou Univ, Fujian Prov Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China

来源：

ACS CATALYSIS | 2023年 / 13卷 / 24期

关键词：

photocatalysis; nickel; cyanation; cyanomethylation; aryl halides; DIRECT ALPHA-ARYLATION; NITRILES; MILD; CYANOACETATE; CHLORIDES; BROMIDES; AMIDES;

D O I：

10.1021/acscatal.3c04745

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Photoinduced nickel-catalyzed demethylative cyanation and decarboxylative cyanomethylation of aryl halides are described here. Commercially available bromoacetonitrile was found to act as an efficient cyanating reagent for the photoinduced cyanation reaction in the absence of a photocatalyst. Moreover, photoredox and nickel dual-catalyzed decarboxylative cyanomethylation of aryl halides has also been realized using cesium cyanoacetate under mild conditions. A series of aryl and benzyl nitriles bearing diverse functional groups were prepared with good to high efficiency.

引用

页码：16279 / 16285

页数：7

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