Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review

被引：1

作者：

Perlot, Q. ^{[1
]}

Hermans, C. ^{[1
,2
]}

Vekemans, M. -C. ^{[1
,2
]}

机构：

[1] Clin Univ St Luc, Serv dhematol, Ave Hippocrate,10, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, IREC, Ave Hippocrate,55-B1 55-05, B-1200 Brussels, Belgium

来源：

REVUE DE MEDECINE INTERNE | 2023年 / 44卷 / 06期

关键词：

Monoclonal Gammopathy; Monoclonal Gammopathy of Clinical; Significance (MGCS); Acquired von Willebrand Syndrome; Acquired Angioedema; VON-WILLEBRAND-SYNDROME; ACQUIRED ANGIOEDEMA; DIAGNOSIS; HEREDITARY;

D O I：

10.1016/j.revmed.2023.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the entity & DLANGBRAC; Monoclonal Gammopathy of Clinical Significance & drangbrac; (MGCS).Case report. - Here, we report two rare cases of MGCS: an acquired von Willebrand syndrome (AvWS) and an acquired angioedema (AAE).Conclusion. - The discovery of a decrease in von Willebrand activity (vWF:RCo) or angioedema in a patient over 50 years of age, in the absence of a family history, should prompt a search for a hemopathy and in particular, a monoclonal gammopathy.& COPY; 2023 Societe Nationale Franc, aise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：307 / 310

页数：4

共 17 条

[1] Efficacy of lanadelumab in acquired angioedema with C1-inhibitor deficiency [J].

Belbezier, Aude ;

Boccon-Gibod, Isabelle ;

Bouillet, Laurence .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (06) :2490-2491

[2] Hereditary Angioedema [J].

Busse, Paula J. ;

Christiansen, Sandra C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (12) :1136-1148

[3] Lymphoproliferative disease and acquired C1 inhibitor deficiency [J].

Castelli, Roberto ;

Deliliers, Daniela Lambertenghi ;

Zingale, Lorenza C. ;

Pogliani, Enrico Maria ;

Cicardi, Marco .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (05) :716-718

[4] Systemic manifestations of monoclonal gammopathy [J].

Decaux, Olivier ;

Laurat, Elisabeth ;

Perlat, Antoinette ;

Cazalets, Claire ;

Jego, Patrick ;

Grosbois, Bernard .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2009, 20 (05) :457-461

[5]

Federici AB, 2000, THROMB HAEMOSTASIS, V84, P345

[6] Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications [J].

Fermand, Jean-Paul ;

Bridoux, Frank ;

Dispenzieri, Angela ;

Jaccard, Arnaud ;

Kyle, Robert A. ;

Leung, Nelson ;

Merlini, Giampaolo .

BLOOD, 2018, 132 (14) :1478-1485

[7] Acquired von Willebrand syndrome: focused for hematologists [J].

Franchini, Massimo ;

Mannucci, Pier Mannuccio .

HAEMATOLOGICA, 2020, 105 (08) :2032-2037

[8] Acquired angioedema due to C1-inhibitor deficiency: CREAK recommendations for diagnosis and treatment [J].

Gobert, D. ;

Bouillet, L. ;

Armengol, G. ;

Coppo, P. ;

Defendi, F. ;

Du-Thanh, A. ;

Hardy, G. ;

Javaud, N. ;

Jeandel, P-Y ;

Launay, D. ;

Panayotopoulos, V ;

Pelletier, F. ;

Boccon-Gibod, I ;

Fain, O. .

REVUE DE MEDECINE INTERNE, 2020, 41 (12) :838-842

[9] A nationwide study of acquired C1-inhibitor deficiency in France Characteristics and treatment responses in 92 patients [J].

Gobert, Delphine ;

Paule, Romain ;

Ponard, Denise ;

Levy, Pierre ;

Fremeaux-Bacchi, Veronique ;

Bouillet, Laurence ;

Boccon-Gibod, Isabelle ;

Drouet, Christian ;

Gayet, Stephane ;

Launay, David ;

Martin, Ludovic ;

Mekinian, Arsene ;

Leblond, Veronique ;

Fain, Olivier .

MEDICINE, 2016, 95 (33)

[10] Prevalence of monoclonal gammopathy of undetermined significance [J].

Kyle, RA ;

Therneau, TM ;

Rajkumar, SV ;

Larson, DR ;

Plevak, MF ;

Offord, JR ;

Dispenzieri, A ;

Katzmann, JA ;

Melton, LJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (13) :1362-1369

← 1 2 →