A rabbit model of tracheal collapse for optimal self-expanding metal stents

被引:1
作者
Kim, Ji Hyun [1 ]
Choi, Jin-Young [2 ]
Yoon, Hun -Young [2 ,3 ,4 ]
机构
[1] VIP Anim Med Ctr, Seoul, South Korea
[2] Konkuk Univ, Coll Vet Med, Dept Vet Surg, Seoul, South Korea
[3] Konkuk Univ, KU Ctr Anim Blood Med Sci, Seoul, South Korea
[4] Konkuk Univ, Coll Vet Med, KU Ctr Anim Blood Med Sci, Dept Vet Surg, 120 Neungdong ro, Seoul 05029, South Korea
关键词
animal model; mechanical properties; rabbit; self-expanding metal stents (SEMS); tracheal collapse; NITINOL STENTS; DOGS; MANAGEMENT;
D O I
10.1292/jvms.22-0167
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Investigating the characteristics of tracheas can help the understanding of diseases related to the trachea, particularly tracheal collapse (TC) in dogs. This study aimed to compare the mechanical properties of tracheas from New Zealand White (NZW) rabbits and dogs and to introduce a method for inducing a model of TC in the normal trachea. Tracheal samples were obtained from NZW rabbit cadavers (n=5) weighing 3.62-3.92 kg and from dog cadavers (n=5) weighing 2.97- 3.28 kg. Three live NZW rabbits weighing 3.5-4.0 kg were used to establish the model. The radial forces of both sample sets were measured using a digital force gauge and statistically compared. Subsequently, TC was surgically induced in three female NZW rabbits by physically weakening their tracheal cartilage under general anesthesia. Their clinical signs were monitored for 3 months, and radiographic examinations were performed monthly for 3 months. The mean radial forces of the two sample sets were comparable (P>0.05). The clinical signs, radiographic examinations, and macroscopic examinations were all comparable to those of dogs with TC. The cadaveric study between the rabbits and dogs demonstrated that the surgically induced rabbit model of TC is an excellent candidate for the experimental study of dogs with TC. This study also provides a reference of tracheal radial force values to enable selection of appropriate mesh types and wire diameters of self-expanding metal stents.
引用
收藏
页码:386 / 392
页数:7
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