Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion

被引：9

作者：

Cai, Xinqi ^{[1
]}

Li, Zhiyang ^{[1
]}

Zhou, Wen-jing ^{[1
]}

Deng, Hui ^{[1
]}

Cao, Xiaoxu ^{[1
]}

Xu, Jieqiong ^{[1
]}

Yin, Zhiwei ^{[1
]}

Wang, Shen ^{[1
]}

Xia, Xin ^{[1
]}

Ma, Chao ^{[2
]}

Chen, Long ^{[3
]}

Ding, Ding ^{[4
]}

Tan, Weihong ^{[1
,4
,5
]}

Chen, Zhuo ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Coll Life Sci, Aptamer Engn Ctr Hunan Prov,Mol Sci & Biomed Lab,S, Changsha 410082, Hunan, Peoples R China

[2] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China

[3] Univ Macau, Fac Sci & Technol, Taipa 999078, Macau, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med IMM, Coll Chem & Chem Engn,Sch Med, Shanghai 200127, Peoples R China

[5] Chinese Acad Sci, Canc Hosp Univ Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou 310022, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 36期

基金：

中国国家自然科学基金;

关键词：

MICROMOTORS; DELIVERY;

D O I：

10.1039/d3cc00933e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic microsweepers with a single-iron-atom center were designed to search for and inhibit Helicobacter pylori. Under dynamic navigation, the microsweepers displayed a large-range wall-adhering reciprocating motion, which increased the opportunity for interaction between microsweepers and H. pylori and further inhibited H. pylori through acid-responsive reactive oxygen species generation.

引用

页码：5455 / 5458

页数：4

共 27 条

[1] An ingestible self-orienting system for oral delivery of macromolecules [J].

Abramson, Alex ;

Caffarel-Salvador, Ester ;

Khang, Minsoo ;

Dellal, David ;

Silverstein, David ;

Gao, Yuan ;

Frederiksen, Morten Revsgaard ;

Vegge, Andreas ;

Hubalek, Frantisek ;

Water, Jorrit J. ;

Friderichsen, Anders V. ;

Fels, Johannes ;

Kirk, Rikke Kaae ;

Cleveland, Cody ;

Collins, Joy ;

Tamang, Siddartha ;

Hayward, Alison ;

Landh, Tomas ;

Buckley, Stephen T. ;

Roxhed, Niclas ;

Rahbek, Ulrik ;

Langer, Robert ;

Traverso, Giovanni .

SCIENCE, 2019, 363 (6427) :611-+

[2] In situ pepsin-assisted needle assembly of magnetic-graphitic-nanocapsules for enhanced gastric retention and mucus penetration [J].

Cai, Xinqi ;

Xu, Yiting ;

Zhao, Lina ;

Xu, Jiamei ;

Li, Shengkai ;

Wen, Chaoqi ;

Xia, Xin ;

Dong, Qian ;

Hu, Xiaoxiao ;

Wang, Xiaofeng ;

Chen, Long ;

Chen, Zhuo ;

Tan, Weihong .

NANO TODAY, 2021, 36

[3] Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori [J].

Chen, Bo-Rui ;

Li, Wei-Ming ;

Li, Tsung-Lin ;

Chan, Yi-Lin ;

Wu, Chang-Jer .

SCIENTIFIC REPORTS, 2022, 12 (01)

[4] Switching from Chemical to Electrical Micromotor Propulsion across a Gradient of Gastric Fluid via Magnetic Rolling [J].

Das, Sankha Shuvra ;

Erez, Shahar ;

Karshalev, Emil ;

Wu, Yue ;

Wang, Joseph ;

Yossifon, Gilad .

ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (26) :30290-30298

[5] Micromotor-enabled active drug delivery for in vivo treatment of stomach infection (vol 8, 272, 2017) [J].

de Avila, Berta Esteban-Fernandez ;

Angsantikul, Pavimol ;

Li, Jinxing ;

Lopez-Ramirez, Miguel Angel ;

Ramirez-Herrera, Doris E. ;

Thamphiwatana, Soracha ;

Chen, Chuanrui ;

Delezuk, Jorge ;

Samakapiruk, Richard ;

Ramez, Valentin ;

Obonyo, Marygorret ;

Zhang, Liangfang ;

Wang, Joseph .

NATURE COMMUNICATIONS, 2017, 8

[6] Multicompartment Tubular Micromotors Toward Enhanced Localized Active Delivery [J].

Esteban-Fernandez de Avila, Berta ;

Lopez-Ramirez, Miguel Angel ;

Mundaca-Uribe, Rodolfo ;

Wei, Xiaoli ;

Ramirez-Herrera, Doris E. ;

Karshalev, Emil ;

Nguyen, Bryan ;

Fang, Ronnie H. ;

Zhang, Liangfang ;

Wang, Joseph .

ADVANCED MATERIALS, 2020, 32 (25)

[7] Single atom electrocatalysts supported on graphene or graphene-like carbons [J].

Fei, Huilong ;

Dong, Juncai ;

Chen, Dongliang ;

Hu, Tiandou ;

Duan, Xidong ;

Shakir, Imran ;

Huang, Yu ;

Duan, Xiangfeng .

CHEMICAL SOCIETY REVIEWS, 2019, 48 (20) :5207-5241

[8] Catalytic antimicrobial robots for biofilm eradication [J].

Hwang, Geelsu ;

Paula, Amauri J. ;

Hunter, Elizabeth E. ;

Liu, Yuan ;

Babeer, Alaa ;

Karabucak, Bekir ;

Stebe, Kathleen ;

Kumar, Vijay ;

Steager, Edward ;

Koo, Hyun .

SCIENCE ROBOTICS, 2019, 4 (29)

[9] Design and evaluation of novel pH-sensitive ureido-conjugated chitosan/TPP nanoparticles targeted to Helicobacter pylori [J].

Jing, Zi-Wei ;

Jia, Yi-Yang ;

Wan, Ning ;

Luo, Min ;

Huan, Meng-Lei ;

Kang, Tai-Bin ;

Zhou, Si-Yuan ;

Zhang, Bang-Le .

BIOMATERIALS, 2016, 84 :276-285

[10] Micro/nanorobots for biomedicine: Delivery, surgery, sensing, and detoxification [J].

Li, Jinxing ;

de Avila, Berta Esteban-Fernandez ;

Gao, Wei ;

Zhang, Liangfang ;

Wang, Joseph .

SCIENCE ROBOTICS, 2017, 2 (04)

← 1 2 3 →