Prenylated flavins: structures and mechanisms

被引：18

作者：

Bloor, Samuel ^{[1
]}

Michurin, Iaroslav ^{[1
]}

Titchiner, Gabriel R. ^{[1
]}

Leys, David ^{[1
]}

机构：

[1] Manchester Inst Biotechnol, Dept Chem, Princess St 131, Manchester M1 7DN, Lancs, England

来源：

FEBS JOURNAL | 2023年 / 290卷 / 09期

基金：

欧洲研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

(de) carboxylation; flavin chemistry; prFMN; UbiD; UbiX; ACID DECARBOXYLASE; OXIDATIVE MATURATION; CRYSTAL-STRUCTURE; CARBOXYLATION; UBIX; BIOSYNTHESIS; CATALYSTS; COENZYME; ALKENES; ENZYME;

D O I：

10.1111/febs.16371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX. A detailed picture of the biochemistry of flavin prenylation, oxidative maturation, and covalent catalysis underpinning reversible decarboxylation is emerging. This reveals the prFMN cofactor can undergo a wide range of transformations, complemented by considerable UbiD-variability. These provide a blueprint for biotechnological applications aimed at producing hydrocarbons or aromatic C-H activation through carboxylation.

引用

页码：2232 / 2245

页数：14

共 55 条

[21] Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts [J].

Gallone, Brigida ;

Steensels, Jan ;

Prahl, Troels ;

Soriaga, Leah ;

Saels, Veerle ;

Herrera-Malaver, Beatriz ;

Merlevede, Adriaan ;

Roncoroni, Miguel ;

Voordeckers, Karin ;

Miraglia, Loren ;

Teiling, Clotilde ;

Steffy, Brian ;

Taylor, Maryann ;

Schwartz, Ariel ;

Richardson, Toby ;

White, Christopher ;

Baele, Guy ;

Maere, Steven ;

Verstrepen, Kevin J. .

CELL, 2016, 166 (06) :1397-+

[22] Selective Aerobic Oxidation of 5-Hydroxymethylfurfural in Water Over Solid Ruthenium Hydroxide Catalysts with Magnesium-Based Supports [J].

Gorbanev, Yury Y. ;

Kegnaes, Soren ;

Riisager, Anders .

CATALYSIS LETTERS, 2011, 141 (12) :1752-1760

[23] The role of UbiX in Escherichia coli coenzyme Q biosynthesis [J].

Gulmezian, Melissa ;

Hyman, Kyle R. ;

Marbois, Beth N. ;

Clarke, Catherine F. ;

Javor, George T. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 467 (02) :144-153

[24] Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate [J].

Hayakawa, Hajime ;

Motoyama, Kento ;

Sobue, Fumiaki ;

Ito, Tomokazu ;

Kawaide, Hiroshi ;

Yoshimura, Tohru ;

Hemmi, Hisashi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (40) :10034-10039

[25]

Huisgen R., 1963, Angew. Chem. Int. Ed, V2, P565, DOI [10.1002/anie.196305651, DOI 10.1002/ANIE.196305651]

[26] A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site [J].

Jacewicz, Agata ;

Trzemecka, Anna ;

Guja, Kip E. ;

Plochocka, Danuta ;

Yakubovskaya, Elena ;

Bebenek, Anna ;

Garcia-Diaz, Miguel .

PLOS ONE, 2013, 8 (10)

[27] Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli [J].

Jervis, Adrian J. ;

Carbonell, Pablo ;

Vinaixa, Maria ;

Dunstan, Mark S. ;

Hollywood, Katherine A. ;

Robinson, Christopher J. ;

Rattray, Nicholas J. W. ;

Yan, Cunyu ;

Swainston, Neil ;

Currin, Andrew ;

Sung, Rehana ;

Toogood, Helen ;

Taylor, Sandra ;

Faulon, Jean-Loup ;

Breitling, Rainer ;

Takano, Eriko ;

Scrutton, Nigel S. .

ACS SYNTHETIC BIOLOGY, 2019, 8 (01) :127-136

[28] Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosa [J].

Kopec, Jolanta ;

Schnell, Robert ;

Schneider, Gunter .

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 67 :1184-1188

[29] Enhanced production of styrene by engineered Escherichia coli and in situ product recovery (ISPR) with an organic solvent [J].

Lee, Kyungsoo ;

Bang, Hyun Bae ;

Lee, Yoon Hyeok ;

Jeong, Ki Jun .

MICROBIAL CELL FACTORIES, 2019, 18 (1)

[30] Flavin metamorphosis: cofactor transformation through prenylation [J].

Leys, David .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2018, 47 :117-125

← 1 2 3 4 5 6 →