Prenylated flavins: structures and mechanisms

被引：18

作者：

Bloor, Samuel ^{[1
]}

Michurin, Iaroslav ^{[1
]}

Titchiner, Gabriel R. ^{[1
]}

Leys, David ^{[1
]}

机构：

[1] Manchester Inst Biotechnol, Dept Chem, Princess St 131, Manchester M1 7DN, Lancs, England

来源：

FEBS JOURNAL | 2023年 / 290卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

(de) carboxylation; flavin chemistry; prFMN; UbiD; UbiX; ACID DECARBOXYLASE; OXIDATIVE MATURATION; CRYSTAL-STRUCTURE; CARBOXYLATION; UBIX; BIOSYNTHESIS; CATALYSTS; COENZYME; ALKENES; ENZYME;

D O I：

10.1111/febs.16371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX. A detailed picture of the biochemistry of flavin prenylation, oxidative maturation, and covalent catalysis underpinning reversible decarboxylation is emerging. This reveals the prFMN cofactor can undergo a wide range of transformations, complemented by considerable UbiD-variability. These provide a blueprint for biotechnological applications aimed at producing hydrocarbons or aromatic C-H activation through carboxylation.

引用

页码：2232 / 2245

页数：14

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