Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14

被引：0
作者：
Arcan, Iris Salamon [1 ]
Kouter, Katarina [1 ,2 ]
Zupanc, Tomaz [3 ]
Paska, Alja Videtic [1 ]
机构：
[1] Univ Ljubljana, Inst Biochem & Mol Genet, Fac Med, Ljubljana, Slovenia
[2] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia
[3] Univ Ljubljana, Inst Forens Med, Fac Med, Ljubljana, Slovenia
来源：
EPIGENOMICS | 2024年 / 16卷 / 10期
关键词：
ADORA2A; B4GALT2; ChIP-seq; chromatin immunoprecipitation; epigenetics; MMP14; sequencing; suicide; PREFRONTAL CORTEX; HISTONE; METHYLATION; DEPRESSION; ADENOSINE; ASSOCIATION; RECEPTORS; BEHAVIOR; VICTIMS; GENES;
D O I：
10.2217/epi-2023-0351
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods: Level of H3K14ac was studied with chromatin immunoprecipitation followed by high-throughput DNA sequencing. Genes were further validated with RT-qPCR; using hippocampal tissue. Results: We showed lowered H3K14ac levels in individuals who died by suicide. The genes ADORA2A, B4GALT2 and MMP14 showed differential expression in individuals who died by suicide. Identified genetic and protein interactions among genes show interactions with suicide-related genes. Conclusion: Further investigations of histone modifications in association with DNA methylation and miRNA are needed to expand our knowledge of the genes that could significantly contribute to suicide.
引用
收藏
页码：701 / 714
页数：14
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