Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14

被引：0
作者：
Arcan, Iris Salamon [1 ]
Kouter, Katarina [1 ,2 ]
Zupanc, Tomaz [3 ]
Paska, Alja Videtic [1 ]
机构：
[1] Univ Ljubljana, Inst Biochem & Mol Genet, Fac Med, Ljubljana, Slovenia
[2] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia
[3] Univ Ljubljana, Inst Forens Med, Fac Med, Ljubljana, Slovenia
来源：
EPIGENOMICS | 2024年 / 16卷 / 10期
关键词：
ADORA2A; B4GALT2; ChIP-seq; chromatin immunoprecipitation; epigenetics; MMP14; sequencing; suicide; PREFRONTAL CORTEX; HISTONE; METHYLATION; DEPRESSION; ADENOSINE; ASSOCIATION; RECEPTORS; BEHAVIOR; VICTIMS; GENES;
D O I：
10.2217/epi-2023-0351
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods: Level of H3K14ac was studied with chromatin immunoprecipitation followed by high-throughput DNA sequencing. Genes were further validated with RT-qPCR; using hippocampal tissue. Results: We showed lowered H3K14ac levels in individuals who died by suicide. The genes ADORA2A, B4GALT2 and MMP14 showed differential expression in individuals who died by suicide. Identified genetic and protein interactions among genes show interactions with suicide-related genes. Conclusion: Further investigations of histone modifications in association with DNA methylation and miRNA are needed to expand our knowledge of the genes that could significantly contribute to suicide.
引用
收藏
页码：701 / 714
页数：14
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共 72 条
  • [41] Abnormal Expression Pattern of Notch Receptors, Ligands, and Downstream Effectors in the Dorsolateral Prefrontal Cortex and Amygdala of Suicidal Victims
    Monsalve, Eva M.
    Garcia-Gutierrez, Maria S.
    Navarrete, Francisco
    Giner, Salvador
    Laborda, Jorge
    Manzanares, Jorge
    [J]. MOLECULAR NEUROBIOLOGY, 2014, 49 (02) : 957 - 965
  • [42] Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate
    Motulsky, Harvey J.
    Brown, Ronald E.
    [J]. BMC BIOINFORMATICS, 2006, 7 (1)
  • [43] Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide
    Nagy, Corina
    Torres-Platas, Susana G.
    Mechawar, Naguib
    Turecki, Gustavo
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2017, 20 (01) : 50 - 57
  • [44] Effects of Postmortem Interval on Biomolecule Integrity in the Brain
    Nagy, Corina
    Maheu, Marissa
    Lopez, Juan Pablo
    Vaillancourt, Kathryn
    Cruceanu, Cristiana
    Gross, Jeffrey A.
    Arnovitz, Mitchell
    Mechawar, Naguib
    Turecki, Gustavo
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2015, 74 (05) : 459 - 469
  • [45] Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain
    Narayan, Pritika J.
    Lill, Claire
    Faull, Richard
    Curtis, Maurice A.
    Dragunow, Mike
    [J]. NEUROBIOLOGY OF DISEASE, 2015, 74 : 281 - 294
  • [46] Epigenetic Basis of Mental Illness
    Nestler, Eric J.
    Pena, Catherine J.
    Kundakovic, Marija
    Mitchell, Amanda
    Akbarian, Schahram
    [J]. NEUROSCIENTIST, 2016, 22 (05) : 447 - 463
  • [47] NIJZ, 2023, SVETOVNI DAN PREPREC
  • [48] Integrated Analysis of microRNA and mRNA Expression Profiles: An Attempt to Disentangle the Complex Interaction Network in Attention Deficit Hyperactivity Disorder
    Nuzziello, Nicoletta
    Craig, Francesco
    Simone, Marta
    Consiglio, Arianna
    Licciulli, Flavio
    Margari, Lucia
    Grillo, Giorgio
    Liuni, Sabino
    Liguori, Maria
    [J]. BRAIN SCIENCES, 2019, 9 (10)
  • [49] Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study
    Oliveira, Silvia
    Ardais, Ana Paula
    Bastos, Clarissa Ribeiro
    Gazal, Marta
    Jansen, Karen
    Souza, Luciano de Mattos
    da Silva, Ricardo Azevedo
    Kaster, Manuella Pinto
    Lara, Diogo Rizzato
    Ghisleni, Gabriele
    [J]. PURINERGIC SIGNALLING, 2019, 15 (01) : 37 - 44
  • [50] Epigenetics and aging
    Pal, Sangita
    Tyler, Jessica K.
    [J]. SCIENCE ADVANCES, 2016, 2 (07):
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