Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14

被引：0
作者：
Arcan, Iris Salamon [1 ]
Kouter, Katarina [1 ,2 ]
Zupanc, Tomaz [3 ]
Paska, Alja Videtic [1 ]
机构：
[1] Univ Ljubljana, Inst Biochem & Mol Genet, Fac Med, Ljubljana, Slovenia
[2] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia
[3] Univ Ljubljana, Inst Forens Med, Fac Med, Ljubljana, Slovenia
来源：
EPIGENOMICS | 2024年 / 16卷 / 10期
关键词：
ADORA2A; B4GALT2; ChIP-seq; chromatin immunoprecipitation; epigenetics; MMP14; sequencing; suicide; PREFRONTAL CORTEX; HISTONE; METHYLATION; DEPRESSION; ADENOSINE; ASSOCIATION; RECEPTORS; BEHAVIOR; VICTIMS; GENES;
D O I：
10.2217/epi-2023-0351
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods: Level of H3K14ac was studied with chromatin immunoprecipitation followed by high-throughput DNA sequencing. Genes were further validated with RT-qPCR; using hippocampal tissue. Results: We showed lowered H3K14ac levels in individuals who died by suicide. The genes ADORA2A, B4GALT2 and MMP14 showed differential expression in individuals who died by suicide. Identified genetic and protein interactions among genes show interactions with suicide-related genes. Conclusion: Further investigations of histone modifications in association with DNA methylation and miRNA are needed to expand our knowledge of the genes that could significantly contribute to suicide.
引用
收藏
页码：701 / 714
页数：14
相关论文
共 72 条
  • [11] Antidepressant Actions of Histone Deacetylase Inhibitors
    Covington, Herbert E., III
    Maze, Ian
    LaPlant, Quincey C.
    Vialou, Vincent F.
    Ohnishi, Yoshinori N.
    Berton, Olivier
    Fass, Dan M.
    Renthal, William
    Rush, Augustus J., III
    Wu, Emma Y.
    Ghose, Subroto
    Krishnan, Vaishnav
    Russo, Scott J.
    Tamminga, Carol
    Haggarty, Stephen J.
    Nestler, Eric J.
    [J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (37) : 11451 - 11460
  • [12] The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors
    Crema, Leonardo M.
    Pettenuzzo, Leticia F.
    Schlabitz, Michele
    Diehl, Luisa
    Hoppe, Juliana
    Mestriner, Regis
    Laureano, Daniela
    Salbego, Christianne
    Dalmaz, Carla
    Vendite, Deusa
    [J]. PHYSIOLOGY & BEHAVIOR, 2013, 109 : 1 - 7
  • [13] Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
    Cunha, RA
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2001, 38 (02) : 107 - 125
  • [14] Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing
    Di Palma, Michael
    Sartini, Stefano
    Lattanzi, Davide
    Cuppini, Riccardo
    Pita-Rodriguez, Mariana
    Diaz-Carmenate, Yoslandy
    Narvaez, Manuel
    Fuxe, Kjell
    Borroto-Escuela, Dasiel O.
    Ambrogini, Patrizia
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2020, 190
  • [15] GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
    Docherty, Anna R.
    Mullins, Niamh
    Ashley-Koch, Allison E.
    Qin, Xuejun
    Coleman, Jonathan R. I.
    Shabalin, Andrey
    Kang, JooEun
    Murnyak, Balasz
    Wendt, Frank
    Adams, Mark
    Campos, Adrian I.
    DiBlasi, Emily
    Fullerton, Janice M.
    Kranzler, Henry R.
    Bakian, Amanda V.
    Monson, Eric T.
    Renteria, Miguel E.
    Walss-Bass, Consuelo
    Andreassen, Ole A.
    Behera, Chittaranjan
    Bulik, Cynthia M.
    Edenberg, Howard J.
    Kessler, Ronald C.
    Mann, J. John
    Nurnberger, John I., Jr.
    Pistis, Giorgio
    Streit, Fabian
    Ursano, Robert J.
    Polimanti, Renato
    Dennis, Michelle
    Garrett, Melanie
    Hair, Lauren
    Harvey, Philip
    Hauser, Elizabeth R.
    Hauser, Michael A.
    Huffman, Jennifer
    Jacobson, Daniel
    Madduri, Ravi
    McMahon, Benjamin
    Oslin, David W.
    Trafton, Jodie
    Awasthi, Swapnil
    Berrettini, Wade H.
    Bohus, Martin
    Chang, Xiao
    Chen, Hsi-Chung
    Chen, Wei J.
    Christensen, Erik D.
    Crow, Scott
    Duriez, Philibert
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2023, 180 (10) : 723 - 738
  • [16] Dora F., 2022, INT J MOL SCI, V23, P1
  • [17] Dwivedi Y, 2009, NEUROPSYCH DIS TREAT, V5, P433
  • [18] On the Genetic and Environmental Relationship Between Suicide Attempt and Death by Suicide
    Edwards, Alexis C.
    Ohlsson, Henrik
    Moscicki, Eve
    Crump, Casey
    Sundquist, Jan
    Lichtenstein, Paul
    Kendler, Kenneth S.
    Sundquist, Kristina
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2021, 178 (11) : 1060 - 1069
  • [19] Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers
    Ernst, C.
    Chen, E. S.
    Turecki, G.
    [J]. MOLECULAR PSYCHIATRY, 2009, 14 (09) : 830 - 832
  • [20] Discovering genetic interactions bridging pathways in genome-wide association studies
    Fang, Gang
    Wang, Wen
    Paunic, Vanja
    Heydari, Hamed
    Costanzo, Michael
    Liu, Xiaoye
    Liu, Xiaotong
    VanderSluis, Benjamin
    Oately, Benjamin
    Steinbach, Michael
    Van Ness, Brian
    Schadt, Eric E.
    Pankratz, Nathan D.
    Boone, Charles
    Kumar, Vipin
    Myers, Chad L.
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
12345678