Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

被引：3
作者：
Guan, Huifang [1 ]
Tian, Jiaxing [2 ]
Wang, Ying [1 ]
Niu, Ping [3 ]
Zhang, Yuxin [2 ]
Zhang, Yanjiao [2 ]
Fang, Xinyi [2 ,4 ]
Miao, Runyu [2 ,4 ]
Yin, Ruiyang [2 ]
Tong, Xiaolin [2 ]
机构：
[1] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun 130117, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Inst Metab Dis, Beijing 100053, Peoples R China
[3] Changchun Univ Chinese Med, Rehabil Dept, Affiliated Hosp, Changchun 130021, Peoples R China
[4] Beijing Univ Chinese Med, Grad Coll, Beijing, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Type 2 diabetes mellitus (T2DM); Macrovascular complications; Secondary prevention; Protective mechanisms; Experimental techniques and methodologies; GLP-1 RECEPTOR AGONISTS; CARDIOVASCULAR RISK-FACTORS; VASCULAR COMPLICATIONS; GLYCEMIC CONTROL; BLOOD-PRESSURE; ANTITHROMBOTIC THERAPY; PLAQUE QUANTIFICATION; INSULIN-RESISTANCE; KIDNEY OUTCOMES; ARTERY-DISEASE;
D O I：
10.1186/s40001-024-01739-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, which have emerged as leading contributors to morbidity and mortality. This review comprehensively explores the pathophysiological mechanisms underlying these complications, protective strategies, and both existing and emerging secondary preventive measures. Furthermore, we delve into the applications of experimental models and methodologies in foundational research while also highlighting current research limitations and future directions. Specifically, we focus on the literature published post-2020 concerning the secondary prevention of macrovascular complications in patients with T2DM by conducting a targeted review of studies supported by robust evidence to offer a holistic perspective.
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页数：34
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