Current understandings of colibactin regulation

被引：6
作者：
Addington, Emily [1 ]
Sandalli, Sofia [1 ]
Roe, Andrew J. [1 ]
机构：
[1] Univ Glasgow, Coll Med Vet & Life Sci, Sch Immun & Inflammat, Glasgow, Scotland
来源：
MICROBIOLOGY-SGM | 2024年 / 170卷 / 02期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
colibactin; regulation; pksisland; colorectal cancer; genotoxin; virulence; ESCHERICHIA-COLI; GENOTOXIN COLIBACTIN; GENOMIC INSTABILITY; SMALL RNA; IN-VIVO; CANCER; BIOSYNTHESIS; INFLAMMATION; RESISTANCE; HYPOXIA;
D O I：
10.1099/mic.0.001427
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA - S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of pks+ bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. Given the genotoxicity of colibactin and the metabolic cost of its synthesis, the regulatory system governing the clb cluster is accordingly highly complex, and many of the mechanisms remain to be elucidated. In this review we summarise the current understanding of regulation of colibactin biosynthesis by internal molecular components and how these factors are modulated by signals from the external environment.
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页数：11
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