Current understandings of colibactin regulation

被引：6
作者：
Addington, Emily [1 ]
Sandalli, Sofia [1 ]
Roe, Andrew J. [1 ]
机构：
[1] Univ Glasgow, Coll Med Vet & Life Sci, Sch Immun & Inflammat, Glasgow, Scotland
来源：
MICROBIOLOGY-SGM | 2024年 / 170卷 / 02期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
colibactin; regulation; pksisland; colorectal cancer; genotoxin; virulence; ESCHERICHIA-COLI; GENOTOXIN COLIBACTIN; GENOMIC INSTABILITY; SMALL RNA; IN-VIVO; CANCER; BIOSYNTHESIS; INFLAMMATION; RESISTANCE; HYPOXIA;
D O I：
10.1099/mic.0.001427
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA - S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of pks+ bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. Given the genotoxicity of colibactin and the metabolic cost of its synthesis, the regulatory system governing the clb cluster is accordingly highly complex, and many of the mechanisms remain to be elucidated. In this review we summarise the current understanding of regulation of colibactin biosynthesis by internal molecular components and how these factors are modulated by signals from the external environment.
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页数：11
相关论文
共 102 条
[61]  
Mousa JJ, 2016, NAT MICROBIOL, V1, DOI [10.1038/nmicrobiol.2015.9, 10.1038/NMICROBIOL.2015.9]
[62]   The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy [J].
Muz, Barbara ;
de la Puente, Pilar ;
Azab, Feda ;
Azab, Abdel Kareem .
HYPOXIA, 2015, 3 :83-92
[63]   Escherichia coli induces DNA double-strand breaks in eukaryotic cells [J].
Nougayrede, Jean-Philippe ;
Homburg, Stefan ;
Taieb, Frederic ;
Boury, Michele ;
Brzuszkiewicz, Elzbieta ;
Gottschalk, Gerhard ;
Buchrieser, Carmen ;
Hacker, Joerg ;
Dobrindt, Ulrich ;
Oswald, Eric .
SCIENCE, 2006, 313 (5788) :848-851
[64]   Oligosaccharides increase the genotoxic effect of colibactin produced by pks plus Escherichia coli strains [J].
Oliero, Manon ;
Calve, Annie ;
Fragoso, Gabriela ;
Cuisiniere, Thibault ;
Hajjar, Roy ;
Dobrindt, Ulrich ;
Santos, Manuela M. .
BMC CANCER, 2021, 21 (01)
[65]   Mutational signature in colorectal cancer caused by genotoxic pks+E. coli [J].
Pleguezuelos-Manzano, Cayetano ;
Puschhof, Jens ;
Huber, Axel Rosendahl ;
van Hoeck, Arne ;
Wood, Henry M. ;
Nomburg, Jason ;
Gurjao, Carino ;
Manders, Freek ;
Dalmasso, Guillaume ;
Stege, Paul B. ;
Paganelli, Fernanda L. ;
Geurts, Maarten H. ;
Beumer, Joep ;
Mizutani, Tomohiro ;
Miao, Yi ;
van der Linden, Reinier ;
van der Elst, Stefan ;
Garcia, K. Christopher ;
Top, Janetta ;
Willems, Rob J. L. ;
Giannakis, Marios ;
Bonnet, Richard ;
Quirke, Phil ;
Meyerson, Matthew ;
Cuppen, Edwin ;
van Boxtel, Ruben ;
Clevers, Hans .
NATURE, 2020, 580 (7802) :269-+
[66]   Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae [J].
Putze, Johannes ;
Hennequin, Claire ;
Nougayrede, Jean-Philippe ;
Zhang, Wenlan ;
Homburg, Stefan ;
Karch, Helge ;
Bringer, Marie-Agnes ;
Fayolle, Corinne ;
Carniel, Elisabeth ;
Rabsch, Wolfgang ;
Oelschlaeger, Tobias A. ;
Oswald, Eric ;
Forestier, Christiane ;
Hacker, Joerg ;
Dobrindt, Ulrich .
INFECTION AND IMMUNITY, 2009, 77 (11) :4696-4703
[67]   Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation [J].
Raisch, Jennifer ;
Buc, Emmanuel ;
Bonnet, Mathilde ;
Sauvanet, Pierre ;
Vazeille, Emilie ;
de Vallee, Amelie ;
Dechelotte, Pierre ;
Darcha, Claude ;
Pezet, Denis ;
Bonnet, Richard ;
Bringer, Marie-Agnes ;
Darfeuille-Michaud, Arlette .
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (21) :6560-6572
[68]   Inorganic Polyphosphate: Essential for Growth and Survival [J].
Rao, Narayana N. ;
Gomez-Garcia, Maria R. ;
Kornberg, Arthur .
ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 :605-647
[69]   Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli [J].
Rehm, Nadine ;
Wallenstein, Alexander ;
Keizers, Marla ;
Homburg, Stefan ;
Magistro, Giuseppe ;
Chagneau, Camille V. ;
Klimek, Hanna ;
Revelles, Olga ;
Helloin, Emmanuelle ;
Putze, Johannes ;
Nougayrede, Jean-Philippe ;
Schubert, Soeren ;
Oswald, Eric ;
Dobrindt, Ulrich .
MBIO, 2022, 13 (01)
[70]   Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli [J].
Sadecki, Patric W. ;
Balboa, Samantha J. ;
Lopez, Lacey R. ;
Kedziora, Katarzyna M. ;
Arthur, Janelle C. ;
Hicks, Leslie M. .
ACS CHEMICAL BIOLOGY, 2021, 16 (07) :1243-1254
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