5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

被引：6
|
作者：
Gautheron, A. [1 ,2 ]
Bernstock, J. D. [3 ,4 ,5 ]
Picart, T. [6 ,7 ]
Guyotat, J. [6 ]
Valdes, P. A. [8 ,9 ,10 ]
Montcel, B. [2 ]
机构：
[1] Univ Jean Monnet St Etienne, Inst Opt Grad Sch, CNRS, Lab Hubert Curien,UMR 5516, F-42023 St Etienne, France
[2] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon,U1294, CREATIS UMR 5220,CNRS,Inserm,UJM St Etienne, Lyon, France
[3] Brigham & Womens Hosp, Dept Neurosurg, Boston, MA USA
[4] Harvard Med Sch, Boston, MA USA
[5] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA USA
[6] Hosp Civils Lyon, Pierre Wertheimer Neurol & Neurosurg Hosp, Dept Neurosurg Oncol & Vasc Neurosurg, Lyon, France
[7] Univ Lyon 1, INSERM 1052, CNRS 5286, Lyon, France
[8] Univ Texas Med Branch, Dept Neurosurg, Galveston, TX USA
[9] Univ Texas Med Branch, Dept Neurobiol, Galveston, TX USA
[10] Rice Univ, Dept Elect & Comp Engn, Houston, TX USA
来源：
FRONTIERS IN NEUROSCIENCE | 2024年 / 18卷
基金：
美国国家卫生研究院;
关键词：
fluorescence spectroscopy; 5-aminolevulinic acid (5-ALA); protoporphyrin IX (PpIX); fluorescence guided surgery; brain tumors; neurooncology; image guidance; neurosurgery; INDUCED PROTOPORPHYRIN-IX; LOW-GRADE GLIOMAS; ALA-INDUCED PPIX; HAND-HELD PROBE; 5-AMINOLEVULINIC ACID; GUIDED SURGERY; BRAIN-TUMORS; OPTICAL SPECTROSCOPY; INDOCYANINE GREEN; QUANTITATIVE FLUORESCENCE;
D O I：
10.3389/fnins.2024.1310282
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.
引用
收藏
页数：17
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