Evaluation of a Vaccine Candidate Designed for Broad-Spectrum Protection against Type A Foot-and-Mouth Disease in Asia

被引：1

作者：

Shin, Sung Ho ^{[1
]}

Hwang, Seong Yun ^{[1
]}

Kim, Hyun-Mi ^{[1
]}

Shin, Se Hee ^{[2
]}

Ko, Mi-Kyeong ^{[1
]}

Lee, Min Ja ^{[1
]}

Kim, Su-Mi ^{[1
]}

Park, Jong-Hyeon ^{[1
]}

机构：

[1] Anim & Plant Quarantine Agcy, Ctr Foot and Mouth Dis Vaccine Res, 177 Hyeoksin 8 Ro, Gimcheon City 39660, Gyeongsangbuk D, South Korea

[2] VAXDIGM, Room 335, 3rd Floor, 11, Bongeunsa Ro 63 Gil, Seoul 060097, South Korea

来源：

VACCINES | 2024年 / 12卷 / 01期

关键词：

foot-and-mouth disease; pig; vaccine; serotype A; broad protection; HETEROLOGOUS CHALLENGE; VIRUS-VACCINE; MIDDLE-EAST; ANTIBODY; SEROTYPE; CATTLE; STRAIN; FMDV;

D O I：

10.3390/vaccines12010064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Foot-and-mouth disease (FMD) vaccines are currently the most powerful protective and preventive measures used to control FMD. In this study, the chimeric vaccine strain containing antigenic epitopes from the FMD virus serotype A, which belongs to the ASIA topotype, was produced and evaluated. The chimeric vaccine strains contain sea-97/G1 (VP4, VP2, VP3) and A22 Iraq (VP1) or G-VII (VP1) for use in FMD vaccines in Asia. The 50% protective dose was determined in mice. Vaccinated mice were challenged with three different type A viruses (Sea-97/G1, Sea-97/G2, G-VII clade) seven days post-vaccination (dpv), and mice that received the vaccine candidates were protected against the three viruses. The protective capability of one of the vaccine candidates was evaluated in pigs. Vaccinated pigs were challenged with three different type A viruses (Sea-97/G1, Sea-97/G2, G-VII clade) at 28 dpv, and pigs that received the vaccine candidate were protected against the three viruses. The results showed that this vaccine candidate, which was designed to provide protection against FMD in Asia, efficiently protected pigs against virus challenge and thus has potential as a broad-spectrum vaccine for various epidemic FMD viruses.

引用

页数：12

共 50 条

[41] Construction of an infectious cDNA clone of foot-and-mouth disease virus type O1BFS 1860 and its use in the preparation of candidate vaccine [J].

Hema, M. ;

Chandran, D. ;

Nagendrakumar, S. B. ;

Madhanmohan, M. ;

Srinivasan, V. A. .

JOURNAL OF BIOSCIENCES, 2009, 34 (01) :45-58

[42] Use of new adjuvants in an emergency vaccine against foot-and-mouth disease virus: Evaluation of conferred immunity [J].

Quattrocchi, V ;

Bianco, V ;

Fondevila, N ;

Pappalardo, S ;

Sadir, A ;

Zamorano, P .

CONTROL OF INFECTIOUS ANIMAL DISEASES BY VACCINATION, 2004, 119 :481-497

[43] Cross-Protection Induced by a A/MAY/97 Emergency Vaccine Against Intra-Serotype Heterologous Challenge with a Foot-and-Mouth Disease Virus from the A/ASIA/G-VII Lineage [J].

Dekker, Aldo ;

Sanz-Bernardo, Beatriz ;

Singanallur, Nagendrakumar Balasubramanian ;

Ludi, Anna B. ;

Horsington, Jacquelyn ;

Eble, Phaedra L. ;

King, Donald P. ;

Vosloo, Wilna .

VACCINES, 2020, 8 (01)

[44] An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV) [J].

Pandya, Mital ;

Pacheco, Juan M. ;

Bishop, Elizabeth ;

Kenney, Mary ;

Milward, Francis ;

Doel, Timothy ;

Golde, William T. .

VACCINE, 2012, 30 (20) :3106-3111

[45] Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle [J].

Mohan, M. S. ;

Gajendragad, M. R. ;

Kishore, Subodh ;

Gopalakrishna, S. ;

Singh, Nem .

VETERINARY RESEARCH COMMUNICATIONS, 2009, 33 (02) :103-109

[46] Potential of a novel flagellin epitope as a broad-spectrum vaccine candidate against enteric fever [J].

Vij, Shania ;

Thakur, Reena ;

Kumari, Laxmi ;

Suri, Chander Raman ;

Rishi, Praveen .

MICROBIAL PATHOGENESIS, 2023, 174

[47] Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle [J].

M. S. Mohan ;

M. R. Gajendragad ;

Subodh Kishore ;

S. Gopalakrishna ;

Nem Singh .

Veterinary Research Communications, 2009, 33 :103-109

[48] Efficacy of synthetic peptide candidate vaccines against serotype-A foot-and-mouth disease virus in cattle [J].

Zhang, Zhongwang ;

Pan, Li ;

Ding, Yaozhong ;

Zhou, Peng ;

Lv, Jianliang ;

Chen, Haotai ;

Fang, Yuzhen ;

Liu, Xinsheng ;

Chang, Huiyun ;

Zhang, Jie ;

Shao, Junjun ;

Lin, Tong ;

Zhao, Furong ;

Zhang, Yongguang ;

Wang, Yonglu .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 99 (03) :1389-1398

[49] Efficacy of synthetic peptide candidate vaccines against serotype-A foot-and-mouth disease virus in cattle [J].

Zhongwang Zhang ;

Li Pan ;

Yaozhong Ding ;

Peng Zhou ;

Jianliang Lv ;

Haotai Chen ;

Yuzhen Fang ;

Xinsheng Liu ;

Huiyun Chang ;

Jie Zhang ;

Junjun Shao ;

Tong Lin ;

Furong Zhao ;

Yongguang Zhang ;

Yonglu Wang .

Applied Microbiology and Biotechnology, 2015, 99 :1389-1398

[50] A ferritin nanoparticle vaccine for foot-and-mouth disease virus elicited partial protection in mice [J].

Chen, Yibao ;

Hu, Yi ;

Chen, Huanchun ;

Li, Xiangmin ;

Qian, Ping .

VACCINE, 2020, 38 (35) :5647-5652

← 1 2 3 4 5 →