The Influence of High Porous Ceramic Implant Based on the ZrO2-Y2O3-Al2O3 System on Vital Indications of Experimental Animals

This article describes the production of nanodisperse xerogel and powders (average CSR size of 9 nm) in the ZrO2-Y2O3-Al2O3 system by coprecipitation of hydroxides. A strong highly porous ceramic has been produced from the initial powder with the composition of [(ZrO2)(0.97)(Y2O3)(0.03)](0.8)(Al2O3)(0.2) with pore forming additives using patented solid phase sintering. Using Doppler sonography, the volume of blood flow in arteriolas and capillaries has been estimated 150 and 250 days after implantation of plates. Therefore, the microcirculatory Doppler sonography seems to be a promising intravital method of estimating blood flow in the zone of plates from biocompatible nonresorbable material and, probably, inside the plates. It has been found that the ceramic plates based on zirconium dioxide in the body of experimental animals do not result in a negative reaction of animal's body. The in vivo experimental results make it possible to state that the obtained bioceramic based on zirconium dioxide is a promising material for endoprosthetics.