Mesenchymal stem cell (MSC)-derived exosomes are recognized as an unparalleled therapy for tissue damage rendered by COVID-19 infection and subsequent hyper-inflammatory immune response. However, the natural targeting mechanism of exosomes is challenging to detect the damaged tissue over long diffusion distances efficiently. The coordinated movement of exosomes is desired for successful identification of target sites. In this work, we propose a molecular communication model, CoTiR, with a bio-inspired directional migration strategy (DMS) for guided propagation of exosomes to target the damaged tissues. The model includes directional propagation, reception, and regeneration of tissue. The proposed model has the potential to be used in designing efficient communication systems in the nanodomain. We compare the proposed model to the basic random propagation model and show the efficacy of our model regarding the detection of multiple targets and the detection time required. Simulation results indicate that the proposed model requires a shorter period of time for a similar number of exosomes to detect the targets compared to the basic random propagation model. Furthermore, the results reveal a 99.96% decrease in the collagen concentration in the absence of inflammatory cytokine molecules compared to the collagen concentration in the presence of inflammatory cytokine molecules.
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
MTA SE Immune Proteogen Res Grp, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Buzas, Edit I.
Toth, Eszter A.
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Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Toth, Eszter A.
Sodar, Barbara W.
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Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Sodar, Barbara W.
Szabo-Taylor, Katalin E.
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Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
机构:
Henan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
He, Jiao
Ren, Weihong
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Ren, Weihong
Wang, Wei
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Wang, Wei
Han, Wenyan
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Han, Wenyan
Jiang, Lu
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Jiang, Lu
Zhang, Dai
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Zhang, Dai
Guo, Mengqi
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Henan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Hu, Peng
Yang, Qinxin
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Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Yang, Qinxin
Wang, Qi
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Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Wang, Qi
Shi, Chenshuo
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Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Shi, Chenshuo
Wang, Dali
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Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Wang, Dali
Armato, Ubaldo
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机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Armato, Ubaldo
Dal Pra, Ilaria
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h-index: 0
机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Dal Pra, Ilaria
Chiarini, Anna
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h-index: 0
机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Jamali, Vahid
Ahmadzadeh, Arman
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机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Ahmadzadeh, Arman
Wicke, Wayan
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机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Wicke, Wayan
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Noel, Adam
Schober, Robert
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机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
MTA SE Immune Proteogen Res Grp, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Buzas, Edit I.
Toth, Eszter A.
论文数: 0引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Toth, Eszter A.
Sodar, Barbara W.
论文数: 0引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Sodar, Barbara W.
Szabo-Taylor, Katalin E.
论文数: 0引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, HungarySemmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
机构:
Henan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
He, Jiao
Ren, Weihong
论文数: 0引用数: 0
h-index: 0
机构:
Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Ren, Weihong
Wang, Wei
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h-index: 0
机构:
Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Wang, Wei
Han, Wenyan
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h-index: 0
机构:
Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Han, Wenyan
Jiang, Lu
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h-index: 0
机构:
Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Jiang, Lu
Zhang, Dai
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Henan Univ Chinese Med, Dept Lab Med, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
Zhang, Dai
Guo, Mengqi
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h-index: 0
机构:
Henan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R ChinaHenan Univ Chinese Med, Clin Med Inst 1, Zhengzhou, Henan, Peoples R China
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Hu, Peng
Yang, Qinxin
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h-index: 0
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Yang, Qinxin
Wang, Qi
论文数: 0引用数: 0
h-index: 0
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Wang, Qi
Shi, Chenshuo
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h-index: 0
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Shi, Chenshuo
Wang, Dali
论文数: 0引用数: 0
h-index: 0
机构:
Zunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R ChinaZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Wang, Dali
Armato, Ubaldo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Armato, Ubaldo
Dal Pra, Ilaria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
Dal Pra, Ilaria
Chiarini, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Univ Verona, Human Histol & Embryol Unit, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyZunyi Med Univ, Dept Burns & Plast Surg, Affiliated Hosp, Dalian Rd 149, Zunyi City 563000, Gui Zhou Provin, Peoples R China
机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Jamali, Vahid
Ahmadzadeh, Arman
论文数: 0引用数: 0
h-index: 0
机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Ahmadzadeh, Arman
Wicke, Wayan
论文数: 0引用数: 0
h-index: 0
机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany
Wicke, Wayan
论文数: 引用数:
h-index:
机构:
Noel, Adam
Schober, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, GermanyFriedrich Alexander Univ Erlangen Nurnberg FAU, Inst Digital Commun, D-91058 Erlangen, Germany