The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases

被引：15

作者：

Song, Ying ^{[1
,2
]}

Wang, Wenjun ^{[1
]}

Wang, Beibei ^{[1
]}

Shi, Qiwen ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Dept Pharmacol, Hangzhou 310014, Zhejiang, Peoples R China

[2] Hangzhou Kings Biopharmaceut Technol Co Ltd, Hangzhou 310007, Zhejiang, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Mitochondrial transcription factor A; Mitochondria; Mitochondrial DNA; Neurodegenerative diseases; TRANSCRIPTION FACTOR; MOUSE MODEL; LIFE-SPAN; PHOSPHORYLATION; OVEREXPRESSION; BIOGENESIS;

D O I：

10.1007/s12035-023-03841-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear genes and transported from the cytoplasm to the mitochondria. TFAM is essential for the maintenance, expression, and delivery of mitochondrial DNA (mtDNA) and can regulate the replication and transcription of mtDNA. TFAM is associated with the formation of mtDNA nucleomimetic structures, mtDNA repair, and mtDNA stability. However, the mechanism by which TFAM protects mtDNA is still being studied. This review provides a summary of the protective mechanism of TFAM on mtDNA including the discrete regulatory effects of TFAM acetylation and phosphorylation on mtDNA, the regulation of Ca2+ levels by TFAM to activate transcription in mitochondria, and the increased binding of TFAM to mtDNA damage hot spots. This review also discusses the association between TFAM and some neurodegenerative diseases.

引用

页码：4381 / 4390

页数：10

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