Modelling systemic risk factors in cardiovascular disease using single-cell biology

被引：0

作者：

Monaco, Claudia ^{[1
]}

Dib, Lea ^{[1
]}

机构：

[1] Univ Oxford, Kennedy Inst, Oxford, England

来源：

NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 06期

关键词：

RHEUMATOID-ARTHRITIS; INFLAMMATION; COLCHICINE; TRIAL;

D O I：

10.1038/s44161-023-00285-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease.

引用

页码：496 / 497

页数：2

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