Modelling systemic risk factors in cardiovascular disease using single-cell biology

被引：0
|
作者：
Monaco, Claudia [1 ]
Dib, Lea [1 ]
机构：
[1] Univ Oxford, Kennedy Inst, Oxford, England
来源：
NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 06期
关键词：
RHEUMATOID-ARTHRITIS; INFLAMMATION; COLCHICINE; TRIAL;
D O I：
10.1038/s44161-023-00285-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease.
引用
收藏
页码：496 / 497
页数：2
相关论文
共 50 条
  • [21] Single-cell RNA sequencing in cardiovascular development, disease and medicine
    David T. Paik
    Sangkyun Cho
    Lei Tian
    Howard Y. Chang
    Joseph C. Wu
    Nature Reviews Cardiology, 2020, 17 : 457 - 473
  • [22] Single-cell RNA sequencing in cardiovascular development, disease and medicine
    Paik, David T.
    Cho, Sangkyun
    Tian, Lei
    Chang, Howard Y.
    Wu, Joseph C.
    NATURE REVIEWS CARDIOLOGY, 2020, 17 (08) : 457 - 473
  • [23] Single-cell sequencing in stem cell biology
    Lu Wen
    Fuchou Tang
    Genome Biology, 17
  • [24] Single-cell microinjection technology in cell biology
    Zhang, Yan
    Yu, Long-Chuan
    BIOESSAYS, 2008, 30 (06) : 606 - 610
  • [25] Single-cell sequencing in stem cell biology
    Wen, Lu
    Tang, Fuchou
    GENOME BIOLOGY, 2016, 17
  • [26] Osteoclast biology in the single-cell era
    Masayuki Tsukasaki
    Hiroshi Takayanagi
    Inflammation and Regeneration, 42
  • [27] The Systems Biology of Single-Cell Aging
    Song, Ruijie
    Sarnoski, Ethan A.
    Acar, Murat
    ISCIENCE, 2018, 7 : 154 - 169
  • [28] Uncovering biology by single-cell proteomics
    M. Shahid Mansuri
    Kenneth Williams
    Angus C. Nairn
    Communications Biology, 6
  • [29] Osteoclast biology in the single-cell era
    Tsukasaki, Masayuki
    Takayanagi, Hiroshi
    INFLAMMATION AND REGENERATION, 2022, 42 (01)
  • [30] Fluidigm pioneers single-cell biology
    Dutton, Gail
    Genetic Engineering and Biotechnology News, 2015, 35 (02): : 8 - 9
12345