Towards in vitro models for reducing or replacing the use of animals in drug testing

被引：38

作者：

Stresser, David M. ^{[1
,2
,3
]}

Kopec, Anna K. ^{[2
,3
,4
]}

Hewitt, Philip ^{[2
,3
,5
]}

Hardwick, Rhiannon N. ^{[2
,3
,6
]}

Van Vleet, Terry R. ^{[2
,3
,7
]}

Mahalingaiah, Prathap Kumar S. ^{[2
,3
,7
]}

O'Connell, Denice ^{[2
,8
,9
]}

Jenkins, Gary J. ^{[1
,2
,10
]}

David, Rhiannon ^{[2
,3
,11
]}

Graham, Jessica ^{[2
,12
,13
,14
]}

Lee, Donna ^{[2
,9
,14
]}

Ekert, Jason ^{[2
,3
,15
]}

Fullerton, Aaron ^{[2
,3
,16
]}

Villenave, Remi ^{[2
,3
,17
]}

Bajaj, Piyush ^{[2
,3
,18
]}

Gosset, James R. ^{[2
,3
,19
]}

Ralston, Sherry L. ^{[2
,9
,20
]}

Guha, Manti ^{[2
,3
,21
]}

Amador-Arjona, Alejandro ^{[2
,3
,21
]}

Khan, Kainat ^{[2
,3
,11
]}

Agarwal, Saket ^{[2
,3
,22
]}

Hasselgren, Catrin ^{[2
,13
,23
]}

Wang, Xiaoting ^{[2
,3
,24
]}

Adams, Khary ^{[2
,9
,25
]}

Kaushik, Gaurav ^{[2
,3
,26
]}

Raczynski, Arkadiusz ^{[2
,3
,27
]}

Homan, Kimberly A. ^{[2
,3
,28
]}

机构：

[1] AbbVie, Quantitat Translat & ADME Sci, N Chicago, IL 60064 USA

[2] Int Consortium Innovat & Qual Pharmaceut Dev IQ, N Chicago, IL 60064 USA

[3] IQ Microphysiol Syst Affiliate IQ, N Chicago, IL 60064 USA

[4] Pfizer Inc, Drug Safety Res & Dev, Groton, CT USA

[5] Merck KGaA, Chem & Preclin Safety, Darmstadt, Germany

[6] Bristol Myers Squibb, Pharmaceut Candidate Optimizat, Discovery Toxicol, San Diego, CA USA

[7] AbbVie, Investigat Toxicol & Pathol, N Chicago, IL USA

[8] AbbVie, Global Anim Welf, N Chicago, IL 60064 USA

[9] IQ 3Rs Replacement Reduct Refinement Translat & P, N Chicago, IL USA

[10] IQ Translat & ADME Sci Leadership Grp TALG, N Chicago, IL USA

[11] AstraZeneca, Clin Pharmacol & Safety Sci, Cambridge, England

[12] Genentech Inc, Prod Qual & Occupat Toxicol, San Francisco, CA 94080 USA

[13] IQ DruSafe, N Chicago, IL USA

[14] Genentech Inc, Safety Assessment, San Francisco, CA 94080 USA

[15] UCB Pharma, Cambridge, MA USA

[16] Genentech Inc, Investigat Toxicol, San Francisco, CA 94080 USA

[17] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland

[18] Sanofi, Global Investigat Toxicol, Preclin Safety, Cambridge, MA USA

[19] Pfizer Inc, Pharmacokinet Dynam & Metab, Med Design, Cambridge, MA USA

[20] AbbVie, Preclin Safety, N Chicago, IL 60064 USA

[21] Incyte, Discovery Biol, Wilmington, DE USA

[22] Alnylam Pharmaceut, Investigat Toxicol, Early Dev, Cambridge, MA USA

[23] Genentech Inc, Predict Toxicol, San Francisco, CA 94080 USA

[24] Amgen Inc, Translat Safety & Bioanalyt Sci, Amgen Res, San Francisco, CA USA

[25] Incyte, Lab Anim Resources, Wilmington, DE USA

[26] Boehringer Ingelheim Pharmaceut Inc, Nonclin Drug Safety, Ridgefield, CT USA

[27] Vertex Pharmaceut Inc, Preclin Safety Assessment, Boston, MA USA

[28] Genentech Inc, Complex In Vitro Syst Grp, San Francisco, CA 94080 USA

来源：

NATURE BIOMEDICAL ENGINEERING | 2024年 / 8卷 / 08期

关键词：

MICROPHYSIOLOGICAL SYSTEMS; INDUSTRY PERSPECTIVE; CLINICAL-TRIALS; SAFETY; CONSORTIUM; CHIP; PHARMACOKINETICS; SUPPORT; UTILITY;

D O I：

10.1038/s41551-023-01154-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements are needed to heighten the models' current state of readiness.

引用

页码：930 / 935

页数：6

共 50 条

[31] Aliskiren Hemifumarate Proliposomes for Improved Oral Drug Delivery: Formulation Development, In Vitro and In Vivo Permeability Testing
Kunamaneni, Priyanka
Kovvasu, Surya
Yeung, Steven
Wang, Jeffrey
Shah, Salim
Betageri, Guru
MOLECULES, 2022, 27 (15):
[32] Simulated synovial fluids for in vitro drug and prodrug release testing of depot injectables intended for joint injection
Thing, Mette
Mertz, Nina
Agardh, Li
Larsen, Susan Weng
Ostergaard, Jesper
Larsen, Claus
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 49 : 169 - 176
[33] Improving animal welfare and reducing animal use for veterinary vaccine potency testing: state of the science and future directions
Stokes, William S.
Brown, Karen
Kulpa-Eddy, Jodie
Srinivas, Geetha
Halder, Marlies
Draayer, Hans
Galvin, Jeffrey
Claassen, Ivo
Gifford, Glen
Woodland, Ralph
Doelling, Vivian
Jones, Brett
INTERNATIONAL WORKSHOP ON ALTERNATIVE METHODS TO REDUCE, REFINE, AND REPLACE THE USE OF ANIMALS IN VACCINE POTENCY AND SAFETY TESTING: STATE OF THE SCIENCE AND FUTURE DIRECTIONS, 2011, 5 : 84 - 105
[34] DynaMiTES - A dynamic cell culture platform for in vitro drug testing PART 2-Ocular DynaMiTES for drug absorption studies of the anterior eye
Beissner, Nicole
Mattern, Kai
Dietzel, Andreas
Reichl, Stephan
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2018, 126 : 166 - 176
[35] Use of Transgenic Mouse Models to Understand the Oral Disposition and Drug-Drug Interaction Potential of Cobimetinib, a MEK Inhibitor
Choo, Edna F.
Woolsey, Sarah
DeMent, Kevin
Ly, Justin
Messick, Kirsten
Qin, Ann
Takahashi, Ryan
DRUG METABOLISM AND DISPOSITION, 2015, 43 (06) : 864 - 869
[36] Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
Sane, Rucha
Cheung, Kit Wun Kathy
Kovacs, Peter
Farasyn, Taleah
Li, Ruina
Bui, Annamaria
Musib, Luna
Kis, Emese
Plise, Emile
Gaborik, Zsuzsanna
DRUG METABOLISM AND DISPOSITION, 2020, 48 (12) : 1264 - 1270
[37] Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems
Marilyn N. Martinez
The AAPS Journal, 2011, 13 : 632 - 649
[38] Trends in the development of human stem cell-based non-animal drug testing models
Lee, Su-Jin
Lee, Hyang-Ae
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2020, 24 (06): : 441 - 452
[39] Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems
Martinez, Marilyn N.
AAPS JOURNAL, 2011, 13 (04): : 632 - 649
[40] HIGH-RISK DRUG USE: EPIDEMIOLOGICAL PATTERN THROUGH HAIR TESTING IN THE FORENSIC CONTEXT
Jose Burgueno, M.
Sanchez, Sergio
Angeles Castro, M.
Mateos-Campos, Ramona
REVISTA ESPANOLA DE SALUD PUBLICA, 2019, 93

← 1 2 3 4 5 →