Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation-Single Center Experience With Large Cohort of Patients

被引:4
作者
Coluzzi, Mariagrazia [1 ,2 ]
Takita, Morihito [3 ]
Saracino, Giovanna [1 ]
Mohammed, Abdul Rub Hakim [4 ]
Darden, Carly M. [1 ]
Testa, Giuliano [1 ]
Beecherl, Ernest [1 ]
Onaca, Nicholas [5 ]
Naziruddin, Bashoo [1 ]
机构
[1] Baylor Univ Med Ctr, Simmons Transplant Inst, Dallas, TX 75246 USA
[2] Azienda Osped Reg San Carlo, Unit Gen & Emergency Surg, Potenza, Italy
[3] Fukushima Med Univ, Dept Radiat Hlth Management, Fukushima, Japan
[4] Baylor Scott & White Res Inst, Dallas, TX USA
[5] LifeGift, Ft Worth, TX USA
关键词
pancreatitis; islet autograft; quality of life; pain; diabetes mellitus; PRESERVING HEAD RESECTION; CELL AUTOTRANSPLANTATION; TRANSPLANTATION; GUIDELINES; MANAGEMENT; DIAGNOSIS; SYMPTOMS; OUTCOMES;
D O I
10.3389/ti.2023.11409
中图分类号
R61 [外科手术学];
学科分类号
摘要
Total pancreatectomy with islet autotransplantation (TPIAT) is the treatment of choice to preserve pancreatic endocrine function, alleviate pain, and improve quality of life (QoL) when other strategies are ineffective for chronic pancreatitis (CP) patients. This study utilized pancreatic disease-specific surveys developed by the European Organisation for Research and Treatment of Cancer (EORTC) to conduct a comprehensive, single-center examination of a large cohort of patients to gain understanding of QoL post-TPIAT. Two validated QoL surveys of the EORTC-QLQ-C30 and QLQ-PAN26-were administered in a prospective cohort of CP patients during pre-and post-operative scheduled visits. A total of 116 patients responded to the preoperative survey and were included in this study. The global health scale of QLQ-C30 was significantly improved after TPIAT when compared to baseline with delta scores of 24.26, 20.54, and 26.7 at 1, 2, and 3 years post-TPIAT (p < 0.001). The EORTC-PAN26 revealed significant improvements in symptom scales for pancreatic pain, bloating, digestive symptoms, taste, indigestion, weight loss, body image, and future worries. The comprehensive surveys in such a large cohort expands the QoL criterion in CP patients and indicates significant improvement in QoL post-TPIAT, further validating TPIAT as a treatment option for refractory CP.
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页数:9
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