The role of B cells in immune cell activation in polycystic ovary syndrome

被引:13
作者
Ascani, Angelo [1 ]
Torstensson, Sara [2 ]
Risal, Sanjiv [2 ]
Lu, Haojiang [2 ]
Eriksson, Gustaw [2 ]
Li, Congru [2 ]
Teschl, Sabrina [1 ]
Menezes, Joana [2 ]
Sandor, Katalin [2 ]
Ohlsson, Claes [3 ,4 ]
Svensson, Camilla I. [2 ]
Karlsson, Mikael C. I. [5 ]
Stradner, Martin Helmut [1 ]
Obermayer-Pietsch, Barbara [1 ]
Stener-Victorin, Elisabet [2 ]
机构
[1] Med Univ Graz, Dept Internal Med, Graz, Austria
[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
[3] Univ Gothenburg, Sahlgrenska Acad, Dept Internal Med & Clin Nutr, Ctr Bone & Arthrit Res, Gothenburg, Sweden
[4] Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, Gothenburg, Sweden
[5] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
来源
ELIFE | 2023年 / 12卷
基金
奥地利科学基金会; 欧盟地平线“2020”; 瑞典研究理事会;
关键词
polycystic ovary syndrome; androgens; B cells; immune; LEVELS INVERSELY CORRELATE; INSULIN-RESISTANCE; IGM ANTIBODIES; EXPRESSION; SUBSETS; INNATE; WOMEN; PREVALENCE; LYMPHOCYTE; MODULATION;
D O I
10.7554/eLife.86454
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here, we demonstrate that B cells are not central mediators of PCOS pathology and that their frequencies are altered as a direct effect of androgen receptor activation. Hyperandrogenic women with PCOS have increased frequencies of age-associated double-negative B memory cells and increased levels of circulating immunoglobulin M (IgM). However, the transfer of serum IgG from women into wild-type female mice induces only an increase in body weight. Furthermore, RAG1 knockout mice, which lack mature T- and B cells, fail to develop any PCOS-like phenotype. In wild-type mice, co-treatment with flutamide, an androgen receptor antagonist, prevents not only the development of a PCOS-like phenotype but also alterations of B cell frequencies induced by dihydrotestosterone (DHT). Finally, B cell-deficient mice, when exposed to DHT, are not protected from developing a PCOS-like phenotype. These results urge further studies on B cell functions and their effects on autoimmune comorbidities highly prevalent among women with PCOS.
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页数:25
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