ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer's Disease

被引：2
作者：
Alves-Borba, Laryssa [1 ,2 ]
Espinosa-Fernandez, Veronica [1 ,2 ]
Canseco-Rodriguez, Ania [1 ,2 ]
Maria Sanchez-Perez, Ana [1 ,2 ]
机构：
[1] Univ Jaume 1, Neurobiotecnol Grp, Fac Hlth Sci, Avda de Vicent Sos Baynat,S N, Castellon de La Plana 12071, Spain
[2] Univ Jaume 1, Inst Adv Mat INAM, Avda de Vicent Sos Baynat,S N, Castellon de La Plana 12071, Spain
来源：
JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期
关键词：
Alzheimer's disease; hippocampus; insulin signal; neuroinflammation; neuroprotector; neurotrophic factor; phytohormones; IMPAIRED INSULIN; EXPRESSION; BRAIN; ALPHA; DEFICITS;
D O I：
10.3233/ADR-230056
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Insulin resistance underlies Alzheimer's disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) intervention on hippocampal BDNF, tumor necrosis factor alpha (TNF alpha), and insulin receptors substrates (IRS) 1/2 mRNA levels in a triple-transgenic mice model of AD. Transgenic mice displayed lower BDNF and IRS2, equal IRS1, and higher TNF alpha expression compared to wild-type mice. Late ABA treatment could rescue TNF alpha and increased IRS1/2 expression. However, early ABA administration was required to increase BDNF expression. Our data suggests that early intervention with ABA can prevent AD, via rescuing IRS1/2 and BDNF expression.
引用
收藏
页码：1007 / 1013
页数：7
相关论文
共 37 条
  • [21] Treatment with 1,25-Dihydroxyvitamin D3 Delays Choroid Plexus Infiltration and BCSFB Injury in MRL/lpr Mice Coinciding with Activation of the PPARγ/NF-κB/TNF-α Pathway and Suppression of TGF-β/Smad Signaling
    Li, Xuewei
    Xu, Shuangli
    Liu, Jie
    Zhao, Yingzhe
    Han, Huirong
    Li, Xiangling
    Wang, Yanqiang
    [J]. INFLAMMATION, 2023, 46 (02) : 556 - 572
  • [22] Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord
    Maixner, Dylan W.
    Christy, David
    Kong, Lingwei
    Viatchenko-Karpinski, Viacheslav
    Horner, Kristen A.
    Hooks, Shelley B.
    Weng, Han-Rong
    [J]. MOLECULAR PAIN, 2022, 18
  • [23] Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    Moloney, Aileen M.
    Griffin, Rebecca J.
    Timmons, Suzanne
    O'Connor, Rosemary
    Ravid, Rivka
    O'Neill, Cora
    [J]. NEUROBIOLOGY OF AGING, 2010, 31 (02) : 224 - 243
  • [24] Brain-derived neurotrophic factor in diabetes mellitus: A systematic review and meta-analysis
    Moosaie, Fatemeh
    Mohammadi, Soheil
    Saghazadeh, Amene
    Firouzabadi, Fatemeh Dehghani
    Rezaei, Nima
    [J]. PLOS ONE, 2023, 18 (02):
  • [25] Evidence that the mouse insulin receptor substrate-1 belongs to the gene family on which the promoter is activated by estrogen receptor α through its interaction with SP1
    Panno, ML
    Mauro, L
    Marsico, S
    Bellizzi, D
    Rizza, P
    Morelli, C
    Salerno, M
    Giordano, F
    Ando, S
    [J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2006, 36 (01) : 91 - 105
  • [26] Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
    Porter, Grace A.
    O'Connor, Jason C.
    [J]. WORLD JOURNAL OF PSYCHIATRY, 2022, 12 (01): : 77 - 97
  • [27] Phosphorylated Tau 181 Serum Levels Predict Alzheimer's Disease in the Preclinical Stage
    Qin, Wei
    Li, Fangyu
    Jia, Longfei
    Wang, Qi
    Li, Ying
    Wei, Yiping
    Li, Yan
    Jin, Hongmei
    Jia, Jianping
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [28] Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
    Ribes-Navarro, Alberto
    Atef, Mariam
    Sanchez-Sarasua, Sandra
    Teresa Beltran-Bretones, Maria
    Olucha-Bordonau, Francisco
    Maria Sanchez-Perez, Ana
    [J]. MOLECULAR NEUROBIOLOGY, 2019, 56 (01) : 454 - 464
  • [29] Alzheimer's disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links
    Rojas, Milagros
    Chavez-Castillo, Mervin
    Bautista, Jordan
    Ortega, Angel
    Nava, Manuel
    Salazar, Juan
    Diaz-Camargo, Edgar
    Medina, Oscar
    Rojas-Quintero, Joselyn
    Bermudez, Valmore
    [J]. WORLD JOURNAL OF DIABETES, 2021, 12 (06)
  • [30] IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis
    Sanchez-Sarasua, Sandra
    Meseguer-Beltran, Maria
    Garcia-Diaz, Cristina
    Beltran-Bretones, Maria Teresa
    ElMlili, Nisrin
    Sanchez-Perez, Ana Maria
    [J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 2022, 118
1234