ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer's Disease

被引：2
作者：
Alves-Borba, Laryssa [1 ,2 ]
Espinosa-Fernandez, Veronica [1 ,2 ]
Canseco-Rodriguez, Ania [1 ,2 ]
Maria Sanchez-Perez, Ana [1 ,2 ]
机构：
[1] Univ Jaume 1, Neurobiotecnol Grp, Fac Hlth Sci, Avda de Vicent Sos Baynat,S N, Castellon de La Plana 12071, Spain
[2] Univ Jaume 1, Inst Adv Mat INAM, Avda de Vicent Sos Baynat,S N, Castellon de La Plana 12071, Spain
来源：
JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期
关键词：
Alzheimer's disease; hippocampus; insulin signal; neuroinflammation; neuroprotector; neurotrophic factor; phytohormones; IMPAIRED INSULIN; EXPRESSION; BRAIN; ALPHA; DEFICITS;
D O I：
10.3233/ADR-230056
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Insulin resistance underlies Alzheimer's disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) intervention on hippocampal BDNF, tumor necrosis factor alpha (TNF alpha), and insulin receptors substrates (IRS) 1/2 mRNA levels in a triple-transgenic mice model of AD. Transgenic mice displayed lower BDNF and IRS2, equal IRS1, and higher TNF alpha expression compared to wild-type mice. Late ABA treatment could rescue TNF alpha and increased IRS1/2 expression. However, early ABA administration was required to increase BDNF expression. Our data suggests that early intervention with ABA can prevent AD, via rescuing IRS1/2 and BDNF expression.
引用
收藏
页码：1007 / 1013
页数：7
相关论文
共 37 条
  • [1] Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis
    Athanasaki, Athanasia
    Melanis, Konstantinos
    Tsantzali, Ioanna
    Stefanou, Maria Ioanna
    Ntymenou, Sofia
    Paraskevas, Sotirios G.
    Kalamatianos, Theodosis
    Boutati, Eleni
    Lambadiari, Vaia
    Voumvourakis, Konstantinos, I
    Stranjalis, George
    Giannopoulos, Sotirios
    Tsivgoulis, Georgios
    Paraskevas, George P.
    [J]. BIOMEDICINES, 2022, 10 (04)
  • [2] Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ
    Bassaganya-Riera, Josep
    Guri, Amir J.
    Lu, Pinyi
    Climent, Montse
    Carbo, Adria
    Sobral, Bruno W.
    Horne, William T.
    Lewis, Stephanie N.
    Bevan, David R.
    Hontecillas, Raquel
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (04) : 2504 - 2516
  • [3] Changes in Brain Function Occur Years before the Onset of Cognitive Impairment
    Beason-Held, Lori L.
    Goh, Joshua O.
    An, Yang
    Kraut, Michael A.
    O'Brien, Richard J.
    Ferrucci, Luigi
    Resnick, Susan M.
    [J]. JOURNAL OF NEUROSCIENCE, 2013, 33 (46) : 18008 - 18014
  • [4] The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats
    Beheshti, Farimah
    Hosseini, Mahmoud
    Hashemzehi, Milad
    Soukhtanloo, Mohammad
    Khazaei, Majid
    Shafei, Mohammad Naser
    [J]. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2019, 22 (08) : 940 - 948
  • [5] Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review
    Berlanga-Acosta, Jorge
    Guillen-Nieto, Gerardo
    Rodriguez-Rodriguez, Nadia
    Luisa Bringas-Vega, Maria
    Garcia-del-Barco-Herrera, Diana
    Berlanga-Saez, Jorge O.
    Garcia-Ojalvo, Ariana
    Joseph Valdes-Sosa, Mitchell
    Valdes-Sosa, Pedro A.
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2020, 11
  • [6] An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
    Bomfim, Theresa R.
    Forny-Germano, Leticia
    Sathler, Luciana B.
    Brito-Moreira, Jordano
    Houzel, Jean-Christophe
    Decker, Helena
    Silverman, Michael A.
    Kazi, Hala
    Melo, Helen M.
    McClean, Paula L.
    Holscher, Christian
    Arnold, Steven E.
    Talbot, Konrad
    Klein, William L.
    Munoz, Douglas P.
    Ferreira, Sergio T.
    De Felice, Fernanda G.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (04) : 1339 - 1353
  • [7] IRS2 takes center stage in the development of type 2 diabetes
    Brady, MJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (07) : 886 - 888
  • [8] Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model
    Choi, Se Hoon
    Bylykbashi, Enjana
    Chatila, Zena K.
    Lee, Star W.
    Pulli, Benjamin
    Clemenson, Gregory D.
    Kim, Eunhee
    Rompala, Alexander
    Oram, Mary K.
    Asselin, Caroline
    Aronson, Jenna
    Zhang, Can
    Miller, Sean J.
    Lesinski, Andrea
    Chen, John W.
    Kim, Doo Yeon
    van Praag, Henriette
    Spiegelman, Bruce M.
    Gage, Fred H.
    Tanzi, Rudolph E.
    [J]. SCIENCE, 2018, 361 (6406) : 991 - +
  • [9] Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity
    Costello, Derek A.
    Claret, Marc
    Al-Qassab, Hind
    Plattner, Florian
    Irvine, Elaine E.
    Choudhury, Agharul I.
    Giese, K. Peter
    Withers, Dominic J.
    Pedarzani, Paola
    [J]. PLOS ONE, 2012, 7 (02):
  • [10] Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats
    Das, Tushar Kanti
    Chakrabarti, Swarup Kumar
    Zulkipli, Ihsan Nazurah
    Hamid, Mas R. W. Abdul
    [J]. JOURNAL OF ALZHEIMERS DISEASE REPORTS, 2019, 3 (01) : 59 - 70
1234