Purpose: The COVID-19 pandemic implied a change in the global order. Considering the characteristics of the Colombian population and the direct repercussions of the virus containment strategies for daily life, this study evaluated the behavioral changes and emotional symptoms during mandatory quarantine associated with the COVID-19 pandemic on the mental health of adolescents and adults. Method: descriptive study with 243 Colombians (age: M=38.05, SD= 17.74) who answered an online questionnaire that inquired about the perception of variations in habits and aspects of daily life during quarantine. Additionally, 63 of them were given the MINI diagnostic interview to assess the presence of emotional affectation. Results: Around half of the population reported that during the quarantine their economic income and physical activity decreased, while their appetite, concern for health and the use of social networks increased. Regarding emotional symptoms, 14.3% presented symptoms of major depression, 17.5% generalized anxiety disorder, 7.9% panic disorder, and 6.3% social phobia. In addition, it was reported that 11.1% of the sample presented black ideas, while 23.8% affirmed having obsessive thoughts. Conclusion: During the confinement associated with the COVID-19 pandemic in Colombia, people reported that in comparison with the daily life before the pandemic, they perceived an increase in the use of social networks, a decreasing physical activity and higher numbers of emotional symptoms and effects on general well-being.