Valproate-Induced Metabolic Syndrome

被引：6

作者：

Shnayder, Natalia A. A. ^{[1
,2
]}

Grechkina, Violetta V. V. ^{[1
]}

Trefilova, Vera V. V. ^{[1
,3
]}

Efremov, Ilya S. S. ^{[4
]}

Dontceva, Evgenia A. A. ^{[2
,5
]}

Narodova, Ekaterina A. A. ^{[2
]}

Petrova, Marina M. M. ^{[2
]}

Soloveva, Irina A. A. ^{[2
]}

Tepnadze, Liia E. E. ^{[2
]}

Reznichenko, Polina A. A. ^{[2
]}

Al-Zamil, Mustafa ^{[6
]}

Altynbekova, Gulnara I. I. ^{[7
]}

Strelnik, Anna I. I. ^{[8
]}

Nasyrova, Regina F. F. ^{[1
,8
]}

机构：

[1] VM Bekhterev Natl Med Res Ctr Psychiat & Neurol, Inst Personalized Psychiat & Neurol, Shared Core Facil, St Petersburg 192019, Russia

[2] VF Voino Yasenetsky Krasnoyarsk State Med Univ, Shared Core Facil Mol & Cell Technol, Krasnoyarsk 660022, Russia

[3] Hosp War Vet, Dept Neurol, St Petersburg 193079, Russia

[4] Bashkir State Med Univ, Dept Psychiat & Narcol, Ufa 450008, Russia

[5] Fed Ctr Neurosurg, Novosibirsk 630087, Russia

[6] Peoples Friendship Univ Russia, Fac Continuing Med Educ, Dept Physiotherapy, Moscow 117198, Russia

[7] SD Asfendiarov Kazakh Natl Med Univ, Dept Psychiat & Narcol, Alma Ata 050022, Kazakhstan

[8] Samara State Med Univ, Int Ctr Educ & Res Neuropsychiat, Samara 443016, Russia

来源：

BIOMEDICINES | 2023年 / 11卷 / 05期

关键词：

valproic acid; metabolic syndrome; personalized approach; metabolomic; metabolome; CHEMOATTRACTANT PROTEIN-1 MCP-1; NECROSIS-FACTOR-ALPHA; ACID-BINDING PROTEIN; INSULIN-RESISTANCE; SODIUM VALPROATE; NEUROPEPTIDE-Y; CARDIOVASCULAR-DISEASE; EPILEPTIC CHILDREN; OXIDATIVE STRESS; GENE-EXPRESSION;

D O I：

10.3390/biomedicines11051499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

引用

页数：35

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