Metal-free transfer hydrogenation/cycloaddition cascade of activated quinolines and isoquinolines with tosyl azides

被引:3
作者
Yadav, Suman [1 ]
Kant, Ruchir [2 ]
Kuram, Malleswara Rao [1 ,3 ]
机构
[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, India
[2] CSIR Cent Drug Res Inst, MSB Div, Lucknow 226031, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
关键词
CYCLIC AMIDINES; BIOLOGICAL EVALUATION; DEAROMATIZATION; REDUCTION;
D O I
10.1039/d3cc01430d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The difficulty in isolating cyclic enamines emanating from their intrinsic instability has impeded their exploration in cycloaddition reactions. Here, we achieved a metal-free domino reaction providing quinoline and isoquinoline-derived cyclic amidines by the cycloaddition of azides with in situ generated enamines via dearomatization.
引用
收藏
页码:7088 / 7091
页数:4
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