Purification of Carrier-Free 47Sc of Biomedical Interest: Selective Separation Study from natCa(n,γ)

被引：9
作者：
El-Din, Ahmed M. Shahr M. [1 ]
Rizk, Hoda E. [2 ]
Attallah, Mohamed F. [1 ]
机构：
[1] Egyptian Atom Energy Author, Hot Labs Ctr, Analyt Chem & Control Dept, POB 13759, Cairo, Egypt
[2] Egyptian Atom Energy Author, Hot Labs Ctr, Nucl Fuel Technol Dept, Cairo 13759, Egypt
来源：
SEPARATIONS | 2023年 / 10卷 / 01期
关键词：
chemical separation; nuclear reactions; radioisotopes production; liquid-liquid extraction; nuclear medicine; theranostic radionuclide Sc-47; LIQUID-LIQUID-EXTRACTION; RARE-EARTH-ELEMENTS; SOLVENT-EXTRACTION; ADDED SC-47; SCANDIUM(III); TITANIUM; ACID; MECHANISM; YTTRIUM; THORIUM;
D O I：
10.3390/separations10010008
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Sc-47 for theranostic medical applications was produced from the neutron activation of a natural calcium target. Liquid-liquid extraction for separation of the Sc-47 radioisotope from Ca-47 was carried out with the extractant Cyanex 272 ((2,4,4-trimethylpentyl) phosphinic acid). The effects of various extraction parameters on the extraction efficiency and separation of the two radionuclides were investigated, including the extraction time, pH, metal ion concentrations, extractant concentration, diluent type, and phase ratio. It was shown that the extraction yield of the Sc-47 radioisotope with the proposed procedure is about 90%, with a fast separation time of 10 min, at pH 1.8 (0.01 M HCl), and with low E (1%) for Ca-47 and high separation factors. The stripping % of the loaded Sc-47 isotope was about 99.2% using 0.4 M oxalic acid solution with a purity of 99.9%.
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页数：11
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