Smoking and coronary artery disease risk in patients with diabetes: A Mendelian randomization study

被引:7
|
作者
Chen, Songzan [1 ,2 ]
Yang, Fangkun [3 ]
Xu, Tian [1 ,2 ]
Wang, Yao [1 ,2 ]
Zhang, Kaijie [1 ,2 ]
Fu, Guosheng [1 ,2 ]
Zhang, Wenbin [1 ,2 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Cardiol, Hangzhou, Peoples R China
[2] Key Lab Cardiovasc Intervent & Regenerat Med Zheji, Hangzhou, Peoples R China
[3] Ningbo First Hosp, Dept Cardiol, Ningbo, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
中国国家自然科学基金;
关键词
mendelian randomization; coronary artery disease; cardiovascular risk factors; smoking; diabetes; CARDIOVASCULAR-DISEASE; GENETIC-VARIANTS; MORTALITY; BIAS;
D O I
10.3389/fimmu.2023.891947
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
BackgroundPrevious observational studies have shown an association between smoking and coronary artery disease (CAD) in patients with diabetes. Whether this association reflects causality remains unestablished. This study aimed to explore the causal effect of smoking on CAD in patients with diabetes. MethodsGenetic signatures for smoking were extracted from a large genome-wide association study (GWAS), consisted of up to 1.2 million participants. Four smoking phenotypes were included: smoking initiation, cigarettes per day, age at initiation of regular smoking, and smoking cessation. Genetic associations with CAD in patients with diabetes were extracted from another GWAS, which included 15,666 participants (3,968 CAD cases and 11,696 controls). The analyses were performed using the univariable and multivariable Mendelian randomization (MR) method. ResultsMR analysis revealed that smoking initiation was positively related to CAD risk in patients with diabetes (OR = 1.322, 95% CI = 1.114 - 1.568, P = 0.001), but this association was attenuated when adjusted for cardiovascular risk factors (OR = 1.212, 95% CI = 1.008 - 1.457, P = 0.041). Age at initiation of regular smoking was negatively related to CAD in patients with diabetes (OR = 0.214, 95% CI = 0.070 - 0.656, P = 0.007), but this association became insignificant when adjusted for cardiovascular risk factors. ConclusionsThis study supported the effect of smoking initiation on the risk of CAD in patients with diabetes.
引用
收藏
页数:7
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