A real-world retrospective observational study exploring NHS resource use in England for the management of moderate-to-severe atopic dermatitis in secondary care for children and adolescents

被引：1

作者：

McPherson, Tess ^{[1
]}

Cork, Michael J. ^{[2
]}

Goodhead, Charlotte ^{[3
]}

Michaelis, Louise J. ^{[4
]}

Flohr, Carsten ^{[5
,6
]}

Petrovic, Milos ^{[7
]}

Hennessy, Liz ^{[8
]}

Rajkovic, Ivana ^{[8
]}

Hudson, Richard ^{[7
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Headlington, England

[2] Sheffield Childrens NHS Fdn Trust, Sheffield, S Yorkshire, England

[3] Royal Victoria Infirm, Newcastle Upon Tyne, Tyne & Wear, England

[4] Great North Childrens Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[5] Guys & St Thomas NHS Fdn Trust, London, England

[6] Kings Coll London, London, England

[7] Sanofi, 410 Thames Valley Pk Dr, Reading RG6 1PT, Berks, England

[8] Adelphi Real World, Bollington, England

来源：

PEDIATRIC DERMATOLOGY | 2023年 / 40卷 / 01期

关键词：

atopic dermatitis; eczema; England; flare; HCRU; prescriptions; QUALITY-OF-LIFE; EUROPEAN GUIDELINES; ECZEMA; IMPACT; ADULTS;

D O I：

10.1111/pde.15134

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Purpose To describe secondary care health care resource utilization (HCRU) for children and adolescents with atopic dermatitis (AD). Patients and Methods This UK chart review of patients with moderate-to-severe AD was conducted in four National Health Service hospitals. Cohorts were defined by age (children 6-11 years, adolescents 12-17) at first consultation. Eligible patients were selected consecutively, starting with the most recently consulting patient. At least 12 months' data were abstracted from medical records. Data were collected on HCRU, demographics/clinical characteristics, treatment, and patient-reported outcomes. Results Data were abstracted for 55 patients. Most patients (80%) had severe AD at first referral, a mean (SD) of 3.2 (10.7) patient-reported flare episodes/patient/year-of-observation, and 18.5 (16.7) tests/scans/procedures/patient/year. Mean (SD) observation duration was 3.6 (1.8) years. Patients had tried mean (SD) 7.9 (5.3) treatments/patient/year of observation. Topical corticosteroids (TCS; 24.5% of prescriptions) were most frequently prescribed. Mean (SD) use of emollients/moisturizers, TCS, systemic corticosteroids, and systemic immunosuppressants was 30.9 (21.3), 21.1 (23.4), 1.7 (8.3), and 7.8 (8.2) months. There was a mean (SD) of 5.3 (2.9) consultations/patient/year-of-observation; 116 (10.7%) for flare. Most hospitalizations (87.5%) were for children; the 8/55 (15%) hospitalized patients (mean 2.0 hospitalizations/patient during observation period) spent 6.2 (SD: 5.1) nights in hospital/hospitalization. Earliest mean (SD) Children's Dermatology Life Quality Index score was 15.3 (7.2); latest was 12.9 (7.5). Conclusion Children and adolescents with moderate-to-severe AD had a high HCRU burden and small changes in quality of life, indicating that current treatments may provide suboptimal AD control in most cases.

引用

页码：50 / 63

页数：14

共 24 条

[1] AN EVALUATION OF THE CURRENT TREATMENT PATHWAYS AND ASSOCIATED NHS RESOURCE USE FOR THE MANAGEMENT OF UNCONTROLLED MODERATE-TO-SEVERE ATOPIC DERMATITIS IN SECONDARY CARE [J].