Aliskiren Copper(II) Complex. Synthesis and Antioxidant Activity

被引：0

作者：

Jori, Nadir ^{[1
]}

Islas, Maria Soledad ^{[1
,2
]}

Ferrer, Evelina Gloria ^{[1
]}

Williams, Patricia Ana Maria ^{[1
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, Ctr Quim Inorgan CEQUINOR CONICET CICPBA UNLP, Blvd 120 1465,CC962 B1900AVV, RA-1900 La Plata, Argentina

[2] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Dept Quim & Bioquim, Funes 3350, RA-7600 Mar Del Plata, Argentina

来源：

JOURNAL OF THE MEXICAN CHEMICAL SOCIETY | 2024年 / 68卷 / 02期

关键词：

N-ligands; copper; antioxidants; EPR; superoxide dismutase; SUPEROXIDE-DISMUTASE; RESONANCE; LIGANDS;

D O I：

10.29356/jmcs.v68i2.1981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aliskiren (Alk) is a highly selective competitive inhibitor of renin used for the treatment of hypertension and related cardiovascular diseases. With the aim of improving its biological properties by the strategy of the induction of favorable conformational changes, we designed a metal -based drug. In this work we report the synthesis of a solid copper(II) complex with aliskiren, CuAlk, and its characterization in solution and solid-state. Moreover, and based on the association of hypertension with elevated levels of reactive oxygen species (ROS), the antioxidant properties of CuAlk were studied measuring the activities against 2,2-diphenyl-1-picrilhidrazil (DPPH center dot), hydroxyl (OH center dot) and peroxyl (ROO center dot) radicals, in addition to its superoxide dismutase (SOD) simil activity. Both the ligand and the complex were able to scavenge hydroxyl radicals, but upon complexation, the SOD mimetic activity of the ligand is enhanced.

引用

页码：210 / 219

页数：10

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