The implications for urological malignancies of non-coding RNAs in the the tumor microenvironment

被引：4

作者：

Wang, Shijin ^{[1
]}

Qi, Xiaochen ^{[1
]}

Liu, Dequan ^{[1
]}

Xie, Deqian ^{[1
]}

Jiang, Bowen ^{[1
]}

Wang, Jin ^{[1
]}

Wang, Xiaoxi ^{[2
]}

Wu, Guangzhen ^{[1
]}

机构：

[1] Dalian Med Univ, Dept Urol, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China

[2] Dalian Med Univ, Dept Clin Lab Med, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China

来源：

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2024年 / 23卷

关键词：

The tumor microenvironment; Non -coding RNA; Urological malignancies; RENAL-CELL CARCINOMA; BLADDER-CANCER PROGRESSION; HUMAN LUNG CANCERS; CIRCULAR RNAS; EXTRACELLULAR-MATRIX; PROSTATE-CANCER; MOLECULAR-MECHANISMS; GENE-EXPRESSION; DOWN-REGULATION; T-CELLS;

D O I：

10.1016/j.csbj.2023.12.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urological malignancies are a major global health issue because of their complexity and the wide range of ways they affect patients. There's a growing need for in-depth research into these cancers, especially at the molecular level. Recent studies have highlighted the importance of non-coding RNAs (ncRNAs) - these don't code for proteins but are crucial in controlling genes - and the tumor microenvironment (TME), which is no longer seen as just a background factor but as an active player in cancer progression. Understanding how ncRNAs and the TME interact is key for finding new ways to diagnose and predict outcomes in urological cancers, and for developing new treatments. This article reviews the basic features of ncRNAs and goes into detail about their various roles in the TME, focusing specifically on how different ncRNAs function and act in urological malignancies.

引用

页码：491 / 505

页数：15

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