Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

被引:18
|
作者
Cizmarikova, Martina [1 ]
Michalkova, Radka [1 ]
Mirossay, Ladislav [1 ]
Mojzisova, Gabriela [2 ]
Zigova, Martina [1 ]
Bardelcikova, Annamaria [1 ]
Mojzis, Jan [1 ]
机构
[1] Pavol Jozef Safarik Univ, Fac Med, Dept Pharmacol, Kosice 04001, Slovakia
[2] Pavol Jozef Safarik Univ, Fac Med, Ctr Clin & Preclin Res MEDIPARK, Kosice, Slovakia
关键词
cancer; hallmarks; ellagic acid; chemoprevention; chemotherapy; CELL-CYCLE ARREST; FACTOR-KAPPA-B; C-MYC EXPRESSION; PROTEIN-KINASE-C; IN-VITRO; DNA-DAMAGE; PANCREATIC-CANCER; SIGNALING PATHWAY; CYTOCHROME-C; MUTANT P53;
D O I
10.3390/biom13111653
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease.
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收藏
页数:42
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