Infantile epileptic spasms syndrome: a cohort study of 88 children

被引:1
作者
Ren, Li-Hong [1 ]
Zhang, Jing [1 ]
Li, Si-Xiu [1 ]
Liu, Ping [1 ]
Chen, Hui [1 ]
Hu, Wenguang [1 ]
机构
[1] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Pediat Neurol, 161, Riyue Ave, Chengdu 611731, Peoples R China
关键词
Infantile epileptic spasms syndrome; Etiology; Risk factors; Etiology-specific; CLINICAL PROFILE; WEST SYNDROME; OUTCOMES;
D O I
10.1186/s13052-023-01563-z
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundThis study aimed to investigate and analyze the risk factors for non-etiology-specific infantile spasms (IS) and unrelieved clinical symptoms after treatment.MethodsEighty-eight children with IS who were treated at our hospital from March 2018 to December 2021 were included in the study. The children were divided into etiology-specific (n = 46) and nonetiology-specific (n = 42) groups, based on the diagnostic results, and remission (n = 45) and nonremission (n = 43) groups, based on clinical outcomes after treatment. The clinical data from patients in the etiology-specific and nonetiology-specific groups and the remission and nonremission groups were compared. Risk factors for non-etiology-specific IS were identified using logistic regression analysis.ResultsGender, family history, birth status, and metabolic abnormalities were significantly different between the etiology-specific and non-etiology-specific groups. Gender and metabolic abnormalities were risk factors for nonetiology-specific IS. Family history, birth status, metabolic abnormalities, and brain magnetic resonance imaging were significantly different between the remission and nonremission groups, and different etiologies were risk factors for unrelieved symptoms after treatment.ConclusionThe occurrence of nonetiology-specific IS is associated with gender and metabolic abnormalities in children. After medication, unrelieved IS symptoms are associated with etiologies.
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页数:6
相关论文
共 36 条
[1]   Impact of therapeutic hypothermia on infantile spasms: an observational cohort study [J].
Abu Dhais, Farah ;
McNamara, Brian ;
O'Mahony, Olivia ;
McSweeney, Niamh ;
Livingstone, Vicki ;
Murray, Deirdre M. ;
Boylan, Geraldine B. .
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2020, 62 (01) :62-68
[2]   Infantile Spasms and West Syndrome - A Clinician's Perspective [J].
Chopra, Saurabh S. .
INDIAN JOURNAL OF PEDIATRICS, 2020, 87 (12) :1040-1046
[3]   Infantile spasms: Assessing the diagnostic yield of an institutional guideline and the impact of etiology on long-term treatment response [J].
Chourasia, Nitish ;
Yuskaitis, Christopher J. ;
Libenson, Mark H. ;
Bergin, Ann M. ;
Liu, Shanshan ;
Zhang, Bo ;
Poduri, Annapurna ;
Harini, Chellamani .
EPILEPSIA, 2022, 63 (05) :1164-1176
[4]   Gender Affects Long-Term Neurological Outcome of Neonates [J].
Freud, Amir ;
Sheiner, Eyal ;
Wainstock, Tamar ;
Landau, Daniella ;
Walfisch, Asnat .
PEDIATRIC NEUROLOGY, 2017, 74 :68-73
[5]   Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies [J].
Galanopoulou, Aristea S. ;
Moshe, Solomon L. .
NEUROBIOLOGY OF DISEASE, 2015, 79 :135-149
[6]   Clinical profile of children with West syndrome: A retrospective chart review [J].
Gehlawat, Virender K. ;
Arya, Vandana ;
Bhardwaj, Harish ;
Vaswani, Narain D. ;
Kaushik, Jaya S. .
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2021, 10 (01) :350-353
[7]   Infantile Spasms (West Syndrome) in Children With Inborn Errors of Metabolism: A Review of the Literature [J].
Gkampeta, Anastasia ;
Pavlou, Evangelos .
JOURNAL OF CHILD NEUROLOGY, 2012, 27 (10) :1295-1301
[8]  
Goswami Mridula, 2021, Int J Clin Pediatr Dent, V14, P323, DOI 10.5005/jp-journals-10005-1922
[9]   Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort [J].
Grinspan, Zachary M. ;
Knupp, Kelly G. ;
Patel, Anup D. ;
Yozawitz, Elissa G. ;
Wusthoff, Courtney J. ;
Wirrell, Elaine ;
Valencia, Ignacio ;
Singhal, Nilika S. ;
Nordli, Douglas R. ;
Mytinger, John R. ;
Mitchell, Wendy ;
Keator, Cynthia G. ;
Loddenkemper, Tobias ;
Hussain, Shaun A. ;
Harini, Chellamani ;
Gaillard, William D. ;
Fernandez, Ivan S. ;
Coryell, Jason ;
Chu, Catherine J. ;
Berg, Anne T. ;
Shellhaas, Renee A. .
NEUROLOGY, 2021, 97 (12) :E1217-E1228
[10]  
Guerrini R, 2003, EPILEPTIC DISORD, V5, pS9