Toll-like receptor 4: A potential therapeutic target for multiple human diseases

被引：23
|
作者：
Wei, Jinrui [1 ,2 ,3 ]
Zhang, Yan [1 ,2 ,3 ]
Li, Haopeng [1 ,2 ,3 ]
Wang, Fuquan [1 ,2 ,3 ]
Yao, Shanglong [1 ,2 ,3 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Inst Anesthesia & Crit Care Med, Tongji Med Coll, Wuhan 430022, Peoples R China
[3] Huazhong Univ Sci & Technol, Key Lab Anesthesiol & Resuscitat, Minist Educ, Hongshan, Peoples R China
[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 166卷
关键词：
Immune response; Toll -like receptor 4; Cardiovascular; Neoplastic; Inflammatory; NF-KAPPA-B; ESOPHAGEAL CANCER-CELLS; TRAUMATIC BRAIN-INJURY; NLRP3; INFLAMMASOME; REGULATORY FACTOR-3; ADHESION MOLECULES; SIGNALING PATHWAYS; ACTIVATION; TLR4; LIPOPOLYSACCHARIDE;
D O I：
10.1016/j.biopha.2023.115338
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.
引用
收藏
页数：9
相关论文
共 50 条
  • [41] Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells
    Yang, Shuan Suo
    Li, Ruogu
    Qu, Xinkai
    Fang, Weiyi
    Quan, Zhe
    CELLULAR IMMUNOLOGY, 2012, 279 (01) : 96 - 102
  • [42] Structure and function of toll-like receptor 8
    Ohto, Umeharu
    Tanji, Hiromi
    Shimizu, Toshiyuki
    MICROBES AND INFECTION, 2014, 16 (04) : 273 - 282
  • [43] The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases
    João-Bruno Soares
    Pedro Pimentel-Nunes
    Roberto Roncon-Albuquerque
    Adelino Leite-Moreira
    Hepatology International, 2010, 4 : 659 - 672
  • [44] Toll-like receptor 4-a multifunctional virus recognition receptor
    Gerber-Tichet, Elina
    Blanchet, Fabien P.
    Majzoub, Karim
    Kremer, Eric J.
    TRENDS IN MICROBIOLOGY, 2025, 33 (01) : 34 - 47
  • [45] The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases
    Soares, Joao-Bruno
    Pimentel-Nunes, Pedro
    Roncon-Albuquerque, Roberto, Jr.
    Leite-Moreira, Adelino
    HEPATOLOGY INTERNATIONAL, 2010, 4 (04) : 659 - 672
  • [46] Salivary and Plasma Levels of Toll-Like Receptor 2 and Toll-Like Receptor 4 in Chronic Periodontitis
    Buduneli, Nurcan
    Ozcaka, Ozgun
    Nalbantsoy, Ayse
    JOURNAL OF PERIODONTOLOGY, 2011, 82 (06) : 878 - 884
  • [47] Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions
    Stephen N. White
    Srinivas R. Kata
    James E. Womack
    Mammalian Genome, 2003, 14 : 149 - 155
  • [48] Toll-like receptors: Role in inflammation and therapeutic potential
    Kay, Emma
    Scotland, Ramona S.
    Whiteford, James R.
    BIOFACTORS, 2014, 40 (03) : 284 - 294
  • [49] Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation
    Li, Jing
    Csakai, Adam
    Jin, Jialin
    Zhang, Fengchun
    Yin, Hang
    CHEMMEDCHEM, 2016, 11 (02) : 154 - 165
  • [50] Toll-like receptor-4 pathway is required for the pathogenesis of human chronic endometritis
    Ju, Jinfen
    Li, Liangpeng
    Xie, Jingyan
    Wu, Yan
    Wu, Xi
    Li, Weihon
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2014, 8 (06) : 1896 - 1900
12345