Risk of Arrhythmic Death in Patients With Nonischemic Cardiomyopathy JACC Review Topic of the Week

被引：7

作者：

Chrispin, Jonathan ^{[1
,15
]}

Merchant, Faisal M. ^{[2
]}

Lakdawala, Neal K. ^{[3
]}

Wu, Katherine C. ^{[4
]}

Tomaselli, Gordon F. ^{[4
]}

Navara, Rachita ^{[5
]}

Torbey, Estelle ^{[6
]}

Ambardekar, Amrut V. ^{[7
]}

Kabra, Rajesh ^{[8
]}

Arbustini, Eloisa ^{[9
]}

Narula, Jagat ^{[10
]}

Guglin, Maya ^{[11
]}

Albert, Christine M. ^{[12
]}

Chugh, Sumeet S. ^{[12
]}

Trayanova, Natalia ^{[13
]}

Cheung, Jim W. ^{[14
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD USA

[2] Emory Univ, Dept Med, Atlanta, GA USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA

[4] Albert Einstein Coll Med, Dept Med, Bronx, NY USA

[5] Univ Calif San Fransisco, Div Cardiac Electrophysiol, California, CA USA

[6] Brown Univ, Div Electrophysiol, Providence, RI USA

[7] Univ Colorado, Dept Med, Div Cardiol, Aurora, CO USA

[8] Kansas City Heart Rhythm Inst, Overland Pk, KS USA

[9] IRCCS Fdn Policlin San Matteo, Ctr Inherited Cardiovasc Dis, Pavia, Italy

[10] Univ Texas Hlth Sci Ctr, McGovern Med Sch, Houston, TX USA

[11] Indiana Univ Sch Med, Adv Heart Failure & Transplant, Indianapolis, IN USA

[12] Cedars Sinai Smidt Heart Inst, Cardiac Electrohysiol, Los Angeles, CA USA

[13] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[14] Weill Cornell Med, Div Cardiol, New York, NY USA

[15] Johns Hopkins Univ, Sch Med, 1800 Orleans St,Zayed 7125, Baltimore, MD 21287 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2023年 / 82卷 / 08期

关键词：

KEY WORDS cardiac magnetic resonance imaging; computational modeling; nonischemic cardiomyopathy; sudden cardiac death; ventricular arrhythmias; SUDDEN CARDIAC DEATH; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; DILATED CARDIOMYOPATHY; HEART-FAILURE; VENTRICULAR-TACHYCARDIA; PRIMARY PREVENTION; SCIENTIFIC STATEMENT; MORTALITY; STRATIFICATION; ASSOCIATION;

D O I：

10.1016/j.jacc.2023.05.064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonischemic cardiomyopathy (NICM) is common and patients are at significant risk for early mortality secondary to ventricular arrhythmias. Current guidelines recommend implantable cardioverter-defibrillator (ICD) therapy to decrease sudden cardiac death (SCD) in patients with heart failure and reduced left ventricular ejection fraction. However, in randomized clinical trials comprised solely of patients with NICM, primary prevention ICDs did not confer significant mortality benefit. Moreover, left ventricular ejection fraction has limited sensitivity and specificity for predicting SCD. Therefore, precise risk stratification algorithms are needed to define those at the highest risk of SCD. This review ex-amines mechanisms of sudden arrhythmic death in patients with NICM, discusses the role of ICD therapy and treatment of heart failure for prevention of SCD in patients with NICM, examines the role of cardiac magnetic resonance imaging and computational modeling for SCD risk stratification, and proposes new strategies to guide future clinical trials on SCD risk assessment in patients with NICM. (J Am Coll Cardiol 2023;82:735-747) & COPY; 2023 by the American College of Cardiology Foundation.

引用

页码：735 / 747

页数：13

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