Protein kinase C: A potential therapeutic target for endothelial dysfunction in diabetes

被引：10
作者：
Xiao, Qian [1 ,2 ]
Wang, Dan [1 ,2 ]
Li, Danyang [2 ]
Huang, Jing [1 ,2 ]
Ma, Feifei [1 ,3 ]
Zhang, Haocheng [1 ,4 ]
Sheng, Yingda [1 ,2 ]
Zhang, Caimei [1 ,2 ]
Ha, Xiaoqin [1 ,2 ]
机构：
[1] Chinese Peoples Liberat Army Joint Secur Force, Dept Lab, Forty Hosp 9, 333 Nanbinhe Middle Rd, Lanzhou 730050, Gansu, Peoples R China
[2] Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China
[3] Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China
[4] Lanzhou Univ, Sch Clin Med 2, Lanzhou 730030, Gansu, Peoples R China
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2023年 / 37卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Protein kinase C; Diabetes mellitus; Endothelial cell; Oxidative stress; Inflammation; AMYLOID PRECURSOR PROTEIN; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; DELTA-PKC; POTASSIUM CHANNELS; ACTIVATION; INHIBITION; GLUCOSE; PHOSPHORYLATION; MECHANISMS;
D O I：
10.1016/j.jdiacomp.2023.108565
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important role in many organs and systems and whose activation contributes significantly to endothelial dysfunction in diabetes. The increase in diacylglycerol (DAG) under high glucose conditions mediates PKC activation and synthesis, which stimulates oxidative stress and inflammation, resulting in impaired endothelial cell function. This article reviews the contribution of PKC to the development of diabetes-related endothelial dysfunction and summarizes the drugs that inhibit PKC activation, with the aim of exploring therapeutic modalities that may alleviate endothelial dysfunction in diabetic patients.
引用
收藏
页数：8
相关论文
共 123 条
[71]   NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions [J].
Nunes, Priscila Rezeck ;
Mattioli, Sarah Viana ;
Sandrim, Valeria Cristina .
CELLS, 2021, 10 (11)
[72]   Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling [J].
Ou, Hsiu-Chung ;
Lee, Wen-Jane ;
Wu, Ching-Mei ;
Chen, Judy Fuh-Meei ;
Sheu, Wayne Huey-Herng .
JOURNAL OF VASCULAR SURGERY, 2012, 55 (04) :1104-1115
[73]   The role of protein kinase C in diabetic microvascular complications [J].
Pan, Deng ;
Xu, Lin ;
Guo, Ming .
FRONTIERS IN ENDOCRINOLOGY, 2022, 13
[74]   Targeting Free Radicals in Oxidative Stress-Related Human Diseases [J].
Poprac, Patrik ;
Jomova, Klaudia ;
Simunkova, Miriama ;
Kollar, Vojtech ;
Rhodes, Christopher J. ;
Valko, Marian .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2017, 38 (07) :592-607
[75]   Endothelial Dysfunction and Its Clinical Implications [J].
Poredos, Pavel ;
Visnovic Poredos, Aleksandra ;
Gregoric, Igor .
ANGIOLOGY, 2021, 72 (07) :604-615
[76]   Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets [J].
Potenza, Maria Assunta ;
Gagliardi, Sara ;
Nacci, Carmela ;
Carratu, Maria Rosaria ;
Montagnani, Monica .
CURRENT MEDICINAL CHEMISTRY, 2009, 16 (01) :94-112
[77]   Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals [J].
Prasad, Sandeo ;
Gupta, Subash C. ;
Tyagi, Amit K. .
CANCER LETTERS, 2017, 387 :95-105
[78]   Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells [J].
Qin, Xia ;
Zhang, Jun ;
Wang, Bin ;
Xu, Ge ;
Yang, Xi ;
Zou, Zhen ;
Yu, Chao .
AUTOPHAGY, 2021, 17 (12) :4266-4285
[79]   Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells [J].
Rainbow, R. D. ;
Hardy, M. E. L. ;
Standen, N. B. ;
Davies, N. W. .
JOURNAL OF PHYSIOLOGY-LONDON, 2006, 575 (03) :833-844
[80]   MYOPLASMIC [CA-2+] DETERMINES MYOSIN PHOSPHORYLATION IN AGONIST-STIMULATED SWINE ARTERIAL SMOOTH-MUSCLE [J].
REMBOLD, CM ;
MURPHY, RA .
CIRCULATION RESEARCH, 1988, 63 (03) :593-603
3456789101112