Protein kinase C: A potential therapeutic target for endothelial dysfunction in diabetes

被引：10

作者：

Xiao, Qian ^{[1
,2
]}

Wang, Dan ^{[1
,2
]}

Li, Danyang ^{[2
]}

Huang, Jing ^{[1
,2
]}

Ma, Feifei ^{[1
,3
]}

Zhang, Haocheng ^{[1
,4
]}

Sheng, Yingda ^{[1
,2
]}

Zhang, Caimei ^{[1
,2
]}

Ha, Xiaoqin ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Joint Secur Force, Dept Lab, Forty Hosp 9, 333 Nanbinhe Middle Rd, Lanzhou 730050, Gansu, Peoples R China

[2] Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

[3] Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China

[4] Lanzhou Univ, Sch Clin Med 2, Lanzhou 730030, Gansu, Peoples R China

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2023年 / 37卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Protein kinase C; Diabetes mellitus; Endothelial cell; Oxidative stress; Inflammation; AMYLOID PRECURSOR PROTEIN; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; DELTA-PKC; POTASSIUM CHANNELS; ACTIVATION; INHIBITION; GLUCOSE; PHOSPHORYLATION; MECHANISMS;

D O I：

10.1016/j.jdiacomp.2023.108565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important role in many organs and systems and whose activation contributes significantly to endothelial dysfunction in diabetes. The increase in diacylglycerol (DAG) under high glucose conditions mediates PKC activation and synthesis, which stimulates oxidative stress and inflammation, resulting in impaired endothelial cell function. This article reviews the contribution of PKC to the development of diabetes-related endothelial dysfunction and summarizes the drugs that inhibit PKC activation, with the aim of exploring therapeutic modalities that may alleviate endothelial dysfunction in diabetic patients.

引用

页数：8

共 123 条

[1] α4β2 nicotinic acetylcholine receptor downregulates D3 dopamine receptor expression through protein kinase C activation [J].