Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea

被引：3

作者：

Huang, Weijun ^{[1
,2
,3
]}

Zhang, Jingyu ^{[1
,2
,3
]}

Zou, Jianyin ^{[1
,2
,3
]}

Wang, Xiaoting ^{[1
,2
,3
]}

Xu, Huajun ^{[1
,2
,3
]}

Guan, Jian ^{[1
,2
,3
]}

Yi, Hongliang ^{[1
,2
,3
]}

Liu, Suru ^{[1
,2
,3
]}

Yin, Shankai ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Otorhinolaryngol Head & Neck Surg, Shanghai Peoples Hosp 6, Sch Med, 600 Yishan Rd, Shanghai, Peoples R China

[2] Shanghai Key Lab Sleep Disordered Breathing, 600 Yishan Rd, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Otolaryngol Inst, 600 Yishan Rd, Shanghai, Peoples R China

来源：

ISCIENCE | 2023年 / 26卷 / 02期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

NONALCOHOLIC FATTY LIVER; INSULIN SENSITIVITY; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; LIPID-METABOLISM; RISK-FACTOR; OBESITY; POPULATION; HYPOPNEA; DISEASE;

D O I：

10.1016/j.isci.2023.105985

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional and longi-tudinal analyses, the FGF21 level was associated with OSA. This analysis of two clinical cohorts is the first to show that the FGF21 level increased signifi-cantly with OSA severity and was an independent predictor of incident OSA in Chinese adults. The circulating FGF21 level could serve as a potential serum biomarker of OSA and its comorbidities and thus aid risk evaluation and early intervention.

引用

页数：19

共 62 条

[11] Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23 [J].

Degirolamo, Chiara ;

Sabba, Carlo ;

Moschetta, Antonio .

NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (01) :51-69

[12] βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism [J].

Ding, Xunshan ;

Boney-Montoya, Jamie ;

Owen, Bryn M. ;

Bookout, Angie L. ;

Coate, Katie Colbert ;

Mangelsdorf, David J. ;

Kliewer, Steven A. .

CELL METABOLISM, 2012, 16 (03) :387-393

[13] Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease [J].

Dushay, Jody ;

Chui, Patricia C. ;

Gopalakrishnan, Gosala S. ;

Varela-Rey, Marta ;

Crawley, Meghan ;

Fisher, Ffolliott M. ;

Badman, Michael K. ;

Martinez-Chantar, Maria L. ;

Maratos-Flier, Eleftheria .

GASTROENTEROLOGY, 2010, 139 (02) :456-463

[14]

Epstein LJ, 2009, J CLIN SLEEP MED, V5, P263

[15] Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State [J].

Fisher, Ffolliott M. ;

Chui, Patricia C. ;

Antonellis, Patrick J. ;

Bina, Holly A. ;

Kharitonenkov, Alexei ;

Flier, Jeffrey S. ;

Maratos-Flier, Eleftheria .

DIABETES, 2010, 59 (11) :2781-2789

[16] Estimation of the Youden index and its associated cutoff point [J].

Fluss, R ;

Faraggi, D ;

Reiser, B .

BIOMETRICAL JOURNAL, 2005, 47 (04) :458-472

[17] Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment [J].

Gaines, Jordan ;

Vgontzas, Alexandros N. ;

Fernandez-Mendoza, Julio ;

Bixler, Edward O. .

SLEEP MEDICINE REVIEWS, 2018, 42 :211-219

[18] The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic [J].

Geng, Leiluo ;

Lam, Karen S. L. ;

Xu, Aimin .

NATURE REVIEWS ENDOCRINOLOGY, 2020, 16 (11) :654-667

[19] Fibroblast growth factor-21, energy balance and obesity [J].

Giralt, Marta ;

Gavalda-Navarro, Aleix ;

Villarroya, Francesc .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 418 :66-73

[20] Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure The Sleep Heart Health Study [J].

Gottlieb, Daniel J. ;

Yenokyan, Gayane ;

Newman, Anne B. ;

O'Connor, George T. ;

Punjabi, Naresh M. ;

Quan, Stuart F. ;

Redline, Susan ;

Resnick, Helaine E. ;

Tong, Elisa K. ;

Diener-West, Marie ;

Shahar, Eyal .

CIRCULATION, 2010, 122 (04) :352-360

← 1 2 3 4 5 6 7 →