Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea

被引：3

作者：

Huang, Weijun ^{[1
,2
,3
]}

Zhang, Jingyu ^{[1
,2
,3
]}

Zou, Jianyin ^{[1
,2
,3
]}

Wang, Xiaoting ^{[1
,2
,3
]}

Xu, Huajun ^{[1
,2
,3
]}

Guan, Jian ^{[1
,2
,3
]}

Yi, Hongliang ^{[1
,2
,3
]}

Liu, Suru ^{[1
,2
,3
]}

Yin, Shankai ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Otorhinolaryngol Head & Neck Surg, Shanghai Peoples Hosp 6, Sch Med, 600 Yishan Rd, Shanghai, Peoples R China

[2] Shanghai Key Lab Sleep Disordered Breathing, 600 Yishan Rd, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Otolaryngol Inst, 600 Yishan Rd, Shanghai, Peoples R China

来源：

ISCIENCE | 2023年 / 26卷 / 02期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

NONALCOHOLIC FATTY LIVER; INSULIN SENSITIVITY; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; LIPID-METABOLISM; RISK-FACTOR; OBESITY; POPULATION; HYPOPNEA; DISEASE;

D O I：

10.1016/j.isci.2023.105985

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional and longi-tudinal analyses, the FGF21 level was associated with OSA. This analysis of two clinical cohorts is the first to show that the FGF21 level increased signifi-cantly with OSA severity and was an independent predictor of incident OSA in Chinese adults. The circulating FGF21 level could serve as a potential serum biomarker of OSA and its comorbidities and thus aid risk evaluation and early intervention.

引用

页数：19

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