Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming

被引:8
作者
Hu, Qifan [1 ,2 ,3 ,4 ]
Li, Yutong [5 ]
Li, Dan [6 ]
Yuan, Yi [7 ]
Wang, Keru [7 ]
Yao, Lu [7 ]
Cheng, Zhujun [8 ]
Han, Tianyu [1 ,2 ,3 ]
机构
[1] Nanchang Univ, Jiangxi Inst Resp Dis, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China
[2] Jiangxi Clin Res Ctr Resp Dis, Nanchang 330006, Jiangxi, Peoples R China
[3] China Japan Friendship Jiangxi Hosp, Natl Reg Ctr Resp Med, Nanchang 330200, Jiangxi, Peoples R China
[4] Nanchang Univ, Sch Basic Med Sci, Nanchang 330031, Jiangxi, Peoples R China
[5] Nanchang Vocat Univ, Nanchang 330500, Jiangxi, Peoples R China
[6] Nanchang Univ, Med Ctr Anesthesiol & Pain, Dept Crit Care Med, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China
[7] Nanchang Univ, Sch Huankui Acad, Nanchang 330031, Jiangxi, Peoples R China
[8] Nanchang Univ, Dept Burn, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Long non-coding RNA; Cancer; Metabolic reprogramming; Amino acid metabolism; LONG NONCODING RNAS; HEPATOCELLULAR-CARCINOMA; PROGRESSION; FERROPTOSIS; METASTASIS; PATHWAY; GROWTH; CLASSIFICATION; PROLIFERATION; LOCALIZATION;
D O I
10.1186/s12964-023-01116-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and survival of cancer cells. Amino acid is one of the key nutrients for cancer cells and many studies have focused on the regulation of amino acid metabolism, including the genetic alteration, epigenetic modification, transcription, translation and post-translational modification of key enzymes in amino acid metabolism. Long non-coding RNAs (lncRNAs) are composed of a heterogeneous group of RNAs with transcripts of more than 200 nucleotides in length. LncRNAs can bind to biological molecules such as DNA, RNA and protein, regulating the transcription, translation and post-translational modification of target genes. Now, the functions of lncRNAs in cancer metabolism have aroused great research interest and significant progress has been made. This review focuses on how lncRNAs participate in the reprogramming of amino acid metabolism in cancer cells, especially glutamine, serine, arginine, aspartate, cysteine metabolism. This will help us to better understand the regulatory mechanism of cancer metabolic reprogramming and provide new ideas for the development of anti-cancer drugs.
引用
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页数:13
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