The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma

被引：61
作者：
Basolo, Fulvio [1 ]
Macerola, Elisabetta [1 ]
Poma, Anello Marcello [1 ]
Torregrossa, Liborio [1 ]
机构：
[1] Univ Pisa, Dept Surg Med Mol Pathol & Crit Area, Via Savi 10, I-56126 Pisa, Italy
来源：
ENDOCRINE | 2023年 / 80卷 / 03期
关键词：
Endocrine pathology; Follicular-derived thyroid cancer; WHO classification system; Diagnostic pathology; ASSOCIATION GUIDELINES; MANAGEMENT; VARIANT; CANCER;
D O I：
10.1007/s12020-023-03336-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The 5(th) edition of the World Health Organization (WHO) classification of endocrine tumors was released in 2022. Several novelties have been introduced concerning the nomenclature and histopathological diagnosis of follicular-derived thyroid neoplasms. Tumor types have been sharply classified according to prognostic risk categories into benign tumors, low-risk neoplasms and malignant neoplasms. A grading system for differentiated thyroid carcinomas has been implemented with the aim of improving the stratification of tumors. Particular attention has been paid to the molecular profile of well-differentiated histotypes. In this review, the main changes introduced by the latest edition of the WHO system are presented. The practical effects on the diagnostic pathology of thyroid tumors, along with the clinical implications expected with the new classification scheme, are critically discussed.
引用
收藏
页码：470 / 476
页数：7
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