Two's Company, Three's a Crowd: Rb1/Trp53/Pten Trifecta and Lung Cancer Molecular and Histopathologic Heterogeneity

被引:1
作者
Yehia, Lamis [1 ]
Centomo, Maria Laura [2 ]
Pandol, Pier Paolo [2 ]
Eng, Charis [1 ,3 ,4 ,5 ,6 ,7 ]
机构
[1] Cleveland Clin, Genom Med Inst, Lerner Res Inst, Cleveland, OH USA
[2] Nevada Syst Higher Educ, William N Pennington Canc Inst, Reno, NV USA
[3] Cleveland Clin, Ctr Personalized Genet Healthcare, Community Care, Cleveland, OH USA
[4] Cleveland Clin, Taussig Canc Inst, Cleveland, OH USA
[5] Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Cleveland, OH USA
[6] Case Western Reserve Univ, Case Comprehens Canc Ctr, Germline High Risk Canc Focus Grp, Cleveland, OH USA
[7] Cleveland Clin, Genom Med Inst, Lerner Res Inst, 9500 Euclid Ave NE50, Cleveland, OH 44195 USA
关键词
PTEN; IMMUNORESISTANCE; RESISTANCE; EXPRESSION; BREAST;
D O I
10.1016/j.jtho.2022.12.011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:260 / 261
页数:2
相关论文
共 13 条
[1]   Subtle variations in Pten dose determine cancer susceptibility [J].
Alimonti, Andrea ;
Carracedo, Arkaitz ;
Clohessy, John G. ;
Trotman, Lloyd C. ;
Nardella, Caterina ;
Egia, Ainara ;
Salmena, Leonardo ;
Sampieri, Katia ;
Haveman, William J. ;
Brogi, Edi ;
Richardson, Andrea L. ;
Zhang, Jiangwen ;
Pandolfi, Pier Paolo .
NATURE GENETICS, 2010, 42 (05) :454-U136
[2]  
Basumallik N., 2022, Nuklearmedizin
[3]   Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer [J].
Bottger, Franziska ;
Semenova, Ekaterina A. ;
Song, Ji-Ying ;
Ferone, Giustina ;
van der Vliet, Jan ;
Cozijnsen, Miranda ;
Bhaskaran, Rajith ;
Bombardelli, Lorenzo ;
Piersma, Sander R. ;
Pham, Thang, V ;
Jimenez, Connie R. ;
Berns, Anton .
CELL REPORTS, 2019, 27 (11) :3345-+
[4]   PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer [J].
Crane, C. A. ;
Panner, A. ;
Murray, J. C. ;
Wilson, S. P. ;
Xu, H. ;
Chen, L. ;
Simko, J. P. ;
Waldman, F. M. ;
Pieper, R. O. ;
Parsa, A. T. .
ONCOGENE, 2009, 28 (02) :306-312
[5]   Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma [J].
George, Suzanne ;
Miao, Diana ;
Demetri, George D. ;
Adeegbe, Dennis ;
Rodig, Scott J. ;
Shukla, Sachet ;
Lipschitz, Mikel ;
Amin-Mansour, Ali ;
Raut, Chandrajit P. ;
Carter, Scott L. ;
Hammerman, Peter ;
Freeman, Gordon J. ;
Wu, Catherine J. ;
Ott, Patrick A. ;
Wong, Kwok-Kin ;
Van Allen, Eliezer M. .
IMMUNITY, 2017, 46 (02) :197-204
[6]   Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer [J].
Lastwika, Kristin J. ;
Wilson, Willie, III ;
Li, Qing Kay ;
Norris, Jeffrey ;
Xu, Haiying ;
Ghazarian, Sharon R. ;
Kitagawa, Hiroshi ;
Kawabata, Shigeru ;
Taube, Janis M. ;
Yao, Sheng ;
Liu, Linda N. ;
Gills, Joell J. ;
Dennis, Phillip A. .
CANCER RESEARCH, 2016, 76 (02) :227-238
[7]   The functions and regulation of the PTEN tumour suppressor: new modes and prospects [J].
Lee, Yu-Ru ;
Chen, Ming ;
Pandolfi, Pier Paolo .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018, 19 (09) :547-562
[8]   Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma [J].
Parsa, Andrew T. ;
Waldron, James S. ;
Panner, Amith ;
Crane, Courtney A. ;
Parney, Ian F. ;
Barry, Jeffrey J. ;
Cachola, Kristine E. ;
Murray, Joseph C. ;
Tihan, Tarik ;
Jensen, Michael C. ;
Mischel, Paul S. ;
Stokoe, David ;
Pieper, Russell O. .
NATURE MEDICINE, 2007, 13 (01) :84-88
[9]   Breast-cancer stromal cells with TP53 mutations and nodal metastases [J].
Patocs, Attila ;
Zhang, Li ;
Xu, Yaomin ;
Weber, Frank ;
Caldes, Trinidad ;
Mutter, George L. ;
Platzer, Petra ;
Eng, Charis .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (25) :2543-2551
[10]   Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy [J].
Peng, Weiyi ;
Chen, Jie Qing ;
Liu, Chengwen ;
Malu, Shruti ;
Creasy, Caitlin ;
Tetzlaff, Michael T. ;
Xu, Chunyu ;
McKenzie, Jodi A. ;
Zhang, Chunlei ;
Liang, Xiaoxuan ;
Williams, Leila J. ;
Deng, Wanleng ;
Chen, Guo ;
Mbofung, Rina ;
Lazar, Alexander J. ;
Torres-Cabala, Carlos A. ;
Cooper, Zachary A. ;
Chen, Pei-Ling ;
Tieu, Trang N. ;
Spranger, Stefani ;
Yu, Xiaoxing ;
Bernatchez, Chantale ;
Forget, Marie-Andree ;
Haymaker, Cara ;
Amaria, Rodabe ;
McQuade, Jennifer L. ;
Glitza, Isabella C. ;
Cascone, Tina ;
Li, Haiyan S. ;
Kwong, Lawrence N. ;
Heffernan, Timothy P. ;
Hu, Jianhua ;
Bassett, Roland L. ;
Bosenberg, Marcus W. ;
Woodman, Scott E. ;
Overwijk, Willem W. ;
Lizee, Gregory ;
Roszik, Jason ;
Gajewski, Thomas F. ;
Wargo, Jennifer A. ;
Gershenwald, Jeffrey E. ;
Radvanyi, Laszlo ;
Davies, Michael A. ;
Hwu, Patrick .
CANCER DISCOVERY, 2016, 6 (02) :202-216